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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 103 - 108 (6page)
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초록· 키워드
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Background/Aims: Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B12 and folate deficiencies in patients with IBD, and to identifythe risk factors associated with abnormal serum vitamin B12 and folate levels. Methods: We evaluated the medical records of195 patients with Crohn’s disease (CD) and 62 patients with ulcerative colitis (UC), and selected 118 healthy subjects for thecontrol group. Results: There were more CD patients with vitamin B12 deficiency than UC patients (14.9% vs. 3.2%, P =0.014)and controls (14.9% vs. 4.2%, P =0.003). The prevalence of folate deficiency was higher in CD patients than in controls (13.3% vs. 3.4%, P =0.004). There were no significant differences in the serum vitamin B12 and folate statuses of the UC and control groups. Patients with prior ileal or ileocolic resection showed a higher prevalence of abnormal vitamin B12 levels than those withoutprior resection (n=6/16, n=23/179; P =0.018). A disease duration within 5 years was a risk factor of abnormal folate levels in CDpatients. Conclusions: This study showed that vitamin B12 and folate deficiencies were more common in patients with CDthan in UC patients and controls. Prior ileal or ileocolonic resection was a risk factor of serum vitamin B12 abnormalities, and adisease duration within 5 years was a risk factor of low serum folate levels in CD patients.
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참고문헌 (20)
참고문헌 신청
O’Leary F / 2010 / Vitamin B12 in health and disease / Nutrients 2:299~316
Krishnaswamy K / 2001 / Importance of folate in human nutrition / Br J Nutr 85(Suppl 2):S115~S124
Yakut M / 2010 / Serum vitamin B12and folate status in patients with inflammatory bowel diseases / Eur J Intern Med 21:320~323
Bermejo F / 2013 / Should we monitor vitamin B12 and folate levels in Crohn’s disease patients? / Scand J Gastroenterol 48:1272~1277
Headstrom PD / 2008 / Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease / Inflamm Bowel Dis 14:217~223
Krishnaswamy K / 2001 / Importance of folate in human nutrition / Br J Nutr 85(Suppl 2):S115~S124
Yakut M / 2010 / Serum vitamin B12and folate status in patients with inflammatory bowel diseases / Eur J Intern Med 21:320~323
Bermejo F / 2013 / Should we monitor vitamin B12 and folate levels in Crohn’s disease patients? / Scand J Gastroenterol 48:1272~1277
Headstrom PD / 2008 / Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease / Inflamm Bowel Dis 14:217~223
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