A Case of Hepatocellular Carcinoma with Pulmonary Metastases Treated Successfully with a Combination of Repeated Hepatic Arterial Infusion Epirubicin and Cisplatin Chemotherapy and  Systemic Low-Dose Infusion of 5-Fluorouracil

Yun-Jung Oh; 박영민; Bo-Hyun Kim; Mi-Jin Kim; Jun-Hyung Cho; Chi-Woon Cha; Sang-Jong Park; Jae-Woo Yeon

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자료유형: 학술저널

저자정보: Yun-Jung Oh 박영민 Bo-Hyun Kim Mi-Jin Kim Jun-Hyung Cho Chi-Woon Cha Sang-Jong Park Jae-Woo Yeon

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제3권 제4호

발행연도: 2009.1

수록면: 343 - 348 (6page)

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We report a case of hepatocellular carcinoma (HCC) with pulmonary metastases treated with repeated hepatic arterial infusion chemotherapy (HAIC) comprising epirubicin and cisplatin, and systemic infusion of 5-fluorouracil (a modified EC/F protocol), which led to complete remission. A 49-year-old man with compensated liver cirrhosis experienced intrahepatic recurrence of HCC with extensive lung metastases. The modified EC/F therapeutic protocol, which was applied at the tenth cycle every 4-5 weeks, resulted in disappearance of the pulmonary metastases and normalization of serum α-fetoprotein levels. A single small HCC lesion was found in the left lobe of the liver 13 months after the final chemotherapy session. HAIC with the same regimen was conducted again, followed by percutaneous intratumoral chemoinjection therapy with 5-fluorouracil and interferon-γ. Thereafter, there was no evidence of recurrence in either the liver or the lung, as evidenced by image analysis and expression of tumor markers. The disease-free intervals for the liver and lung were 41 and 54 months, respectively.

#Carcinoma #Hepatocellular #Lung metastasis #Hepatic arterial infusion chemotherapy #Drug therapy

참고문헌 (22)

참고문헌 신청

Anami Y / 2005 / Complete disappearance of metastatic lung tumors and mediastinal lymphnode in a case of hepatocellular carcinoma treated by low-dose 5-fluorouracil/cisplati

Ando E / 1997 / A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein / Cancer 79 : 1890 ~ 1896

Bruix J / 2002 / Prognostic prediction and treatment strategy in hepatocellular carcinoma / Hepatology 35 : 519 ~ 524

Enoki T / 2007 / A case of multiple lung metastases of hepatocellular carcinoma after resection of liver and tumor thrombi in the inferior vena cava responding to chemotherap

Falkson G / 1984 / Primary liver cancer: an Eastern Cooperative Oncology Group Trial / Cancer 54 : 970 ~ 977

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