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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 120 - 129 (10page)
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Background/Aims: Combination treatment consisting of hepatic arterial infusion chemotherapy with epirubicin and cisplatin (HAIC-EC) and systemic infusion of low-dose 5-fluorouracil (5-FU) are sometimes effective against advanced hepatocellular carcinoma (HCC). However, there is no effective treatment for advanced HCCs with arterioportal shunts (APS) or arteriovenous shunts (AVS). Methods:We investigated a response and adverse events of a new combination protocol of repeated HAIC-EC and percutaneous intratumoral injection chemotherapy with a mixture of recombinant interferon-gamma (IFN-γ) and 5-FU (PIC-IF) in patients with far-advanced HCCs with large APSs or AVSs. Results: There was a complete response (CR) for the large vascular shunts in all three patients and for all tumor burdens in two patients. Significant side effects were flu-like symptoms (grade 2) and bone marrow suppression (grade 2 or 3) after each cycle, but these were well-tolerated. Conclusions: These results suggest that the combination of HAIC-EC and PIC-IF is a new and promising approach for advanced HCC accompanied by a large APS or AVS.
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참고문헌 (19)
참고문헌 신청
Beatty G / 2001 / IFN-gamma-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4+ T cells requires tumor responsiveness to IFN-gamma / J Immunol 166 : 2276 ~
Chung C / 2007 / Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarci
Eun JR / 2009 / Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-alpha for the treatment of advanced hepatocellu
Hirabayashi N / 1985 / In vitro chemosensitivity tests on human tumor xenografts by clonogenic assay: the combined use of mitomycin C with alpha- interferon or gamma-interfe
Hiyoshi Y / 2007 / The efficacy of transcatheter embolization of severe arterioportal shunts in hepatocellular carcinoma / Gan To Kagaku Ryoho 34 : 2093 ~ 2095
Chung C / 2007 / Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarci
Eun JR / 2009 / Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-alpha for the treatment of advanced hepatocellu
Hirabayashi N / 1985 / In vitro chemosensitivity tests on human tumor xenografts by clonogenic assay: the combined use of mitomycin C with alpha- interferon or gamma-interfe
Hiyoshi Y / 2007 / The efficacy of transcatheter embolization of severe arterioportal shunts in hepatocellular carcinoma / Gan To Kagaku Ryoho 34 : 2093 ~ 2095
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