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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 423 - 427 (5page)
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Treatment with sorafenib prolongs both the median survival and time to progression by nearly 3 months in patients with advanced hepatocellular carcinoma.
Although the effects of combining sorafenib therapy with other anticancer treatment modalities have not been clarified, combination treatment is strongly expected to be beneficial. We report the case of a 50-year-old man who exhibited a partial response and portal vein thrombosis (PVT) revascularization after sorafenib combined with hepatic arterial infusion chemotherapy (HAIC). He exhibited a decrease in tumor size and PVT after 2 months of sorafenib monotherapy.
However, no additional response was seen during the subsequent 2 months. To achieve a better tumor response, we combined HAIC with sorafenib.
Daily cisplatin (7 mg/m2 on days 1-5) and 5-fluorouracil (170 mg/m2 on days 1-5) were infused repeatedly every 4 weeks, and the sorafenib prescription was modified. After four cycles of combined therapy, both the tumor size and PVT were much improved and exhibited partial response.
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참고문헌 (22)
참고문헌 신청
Ando E / 1997 / A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein / Cancer 79 (`) : 1880 ~ 1896
Asahara T / 1999 / Hepatic resection with tumor thrombectomy for hepatocellular carcinoma with tumor thrombi in the major vasculatures / Hepatogastroenterology 46 : 1862 ~ 18
Bruix J / 2005 / Management of hepatocellular carcinoma / Hepatology 42 : 1208 ~ 1236
Chen SC / 1994 / The effect of external radiotherapy in treatment of portal vein invasion in hepatocellular carcinoma / Cancer Chemother Pharmacol 33 (Suppl) : S124 ~ S127
Furuse J / 1997 / Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal sh / Radiology 204 : 787 ~ 790
Asahara T / 1999 / Hepatic resection with tumor thrombectomy for hepatocellular carcinoma with tumor thrombi in the major vasculatures / Hepatogastroenterology 46 : 1862 ~ 18
Bruix J / 2005 / Management of hepatocellular carcinoma / Hepatology 42 : 1208 ~ 1236
Chen SC / 1994 / The effect of external radiotherapy in treatment of portal vein invasion in hepatocellular carcinoma / Cancer Chemother Pharmacol 33 (Suppl) : S124 ~ S127
Furuse J / 1997 / Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal sh / Radiology 204 : 787 ~ 790
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