Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis

Youn Zoo Cho; Yoon Ok Jang; Yong Seok Kang; 김문영; Eunhee Choi; Yoo Li Lim; 권상옥; 백순구

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자료유형: 학술저널

저자정보: Youn Zoo Cho Yoon Ok Jang Yong Seok Kang 김문영 Eunhee Choi Yoo Li Lim 권상옥 백순구

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제10권 제1호

발행연도: 2016.1

수록면: 109 - 116 (8page)

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Background/Aims: Levels of serum apelin (s-apelin), an endogenous ligand for angiotensin-like receptor 1, have been shown to be related to hepatic fibrosis and hemodynamic abnormalities in preclinical studies. We investigated the clinical implications of s-apelin as a noninvasive prognostic biomarker for chronic liver disease (CLD). Methods: From January 2009 to December 2012, 215 CLD patients were enrolled and underwent clinical data collection, hepatic venous pressure gradient (HVPG) measurement, and liver biopsy. s-apelin was detected with a human total apelin enzyme-linked immunosorbent assay kit. All patients were prospectively observed during the median follow-up period of 23.0±12.9 months for decompensation and mortality. Results: A total of 42 patients (19.5%) died during the follow-up period. s-apelin was significantly correlated with measurements of liver stiffness (R2=0.263, p<0.001) and collagen proportional area (R2=0.213, p<0.001) measured from liver biopsy tissue and HVPG (R2=0.356, p<0.001). In a multivariate analysis using a Cox regression hazard model, s-apelin was a weakly significant predictor of decompensation (hazard ratio [HR], 1.002; p<0.001) and mortality (HR, 1.003; p<0.001). Conclusions: s-apelin showed a significant relationship with CLD severity. However, its significance as a noninvasive biomarker for disease severity and prognosis was weak.

#Apelin #Portal hypertension #Liver cirrhosis #Prognosis #Biological markers

참고문헌 (21)

참고문헌 신청

Arvaniti V / 2010 / Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis / Gastroenterology 139:1246~1256

Garcia-Tsao G / 2010 / Now there are many (stages) where before there was one: in search of a pathophysiological classification of cirrhosis / Hepatology 51:1445~1449

Kim MY / 2010 / Hemodynamic alterations in cirrhosis and portal hypertension / Korean J Hepatol 16:347~352

박의주 / 2013 / The Risk Factors for Bleeding of Fundal Varices in Patients with Liver Cirrhosis / Gut and Liver 7(6):704~711

이태훈 / 2013 / Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: An Enhanced Model of BARD Score / Gut and Liver 7(3):323~328

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