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논문 기본 정보

자료유형
학술저널
저자정보
Michael H. Le (Larner College of Medicine at the University of Vermont, Burlington, VT, USA; Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA) David M. Le (Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA; Burrell College of Osteopathic Medicine, Las Cruces, NM, USA) Thomas C. Baez (Burrell College of Osteopathic Medicine, Las Cruces, NM, USA) Hansen Dang (Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA; Carver College of Medicine at the University of Iowa, Iowa City, IA, USA) Vy H. Nguyen (Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA; Harvard Medical School, Boston, MA, USA) KeeSeok Lee (Stanford University, Stanford, CA, USA) Christopher D. Stave (Lane Library, Stanford University School of Medicine, Stanford, CA, USA) Takanori Ito (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan) Yuankai Wu (Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China) Yee Hui Yeo (The Karsh Division of Gastroenterology and Hepatology, Cedars Sinai Medical Center, Los Angeles, CA, USA) Fanpu Ji (Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; National) Ramsey Cheung (Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA; Division of Gastroenterology and Hepatology, Palo Alto Veterans Affairs Medical Center, P) Mindie H. Nguyen (Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA; Department of Epidemiology and Population Health, Stanford University Medical Center, Pal)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.2
발행연도
2024.4
수록면
235 - 246 (12page)

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초록· 키워드

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Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is associated with a multitude of adverse outcomes. We aimed to estimate the pooled incidence of NAFLD-related adverse events. Methods: We performed a systematic review and meta-analysis of cohort studies of adults with NAFLD to evaluate the pooled incidence of adverse events. Results: 19,406 articles were screened, 409 full-text articles reviewed, and 79 eligible studies (1,377,466 persons) were included. Mean age was 51.47 years and body mass index 28.90 kg/m2. Baseline comorbidities included metabolic syndrome (41.73%), cardiovascular disease (CVD) (16.83%), cirrhosis (21.97%), and nonalcoholic steatohepatitis (NASH) (58.85%). Incidence rate per 1,000 person-years for mortality included: all-cause (14.6), CVD-related (4.53), non-liver cancer-related (4.53), and liver-related (3.10). Incidence for liver-related events included overall (24.3), fibrosis progression (49.0), cirrhosis (10.9), liver transplant (12.0), and hepatocellular carcinoma (HCC) (3.39). Incidence for non-liver events included metabolic syndrome (25.4), hypertension (25.8), dyslipidemia (26.4), diabetes (19.0), CVD (24.77), renal impairment (30.3), depression/anxiety (29.1), and non-liver cancer (10.5). Biopsy-proven NASH had higher incidence of HCC (P=0.043) compared to non-NASH. Higher rates of CVD and mortality were observed in North America and Europe, hypertension and non-liver cancer in North America, and HCC in Western Pacific/Southeast Asia (P<0.05). No significant differences were observed by sex. Time-period analyses showed decreasing rates of cardiovascular and non-liver cancer mortality and increasing rates of decompensated cirrhosis (P<0.05). Conclusions: People with NAFLD have high incidence of liver and non-liver adverse clinical events, varying by NASH, geographic region, and time-period, but not sex.
#NAFLD #Cirrhosis #Meta-analysis #Epidemiology

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