The Effect of the First Spontaneous Bacterial Peritonitis Event on the Mortality of Cirrhotic Patients with Ascites: A Nationwide Population-Based Study in Taiwan

Tsung-Hsing Hung; Chen-Chi Tsai; Yu-Hsi Hsieh; Chih-Chun Tsai; Chih-Wei Tseng; Kuo-Chih Tseng

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자료유형: 학술저널

저자정보: Tsung-Hsing Hung Chen-Chi Tsai Yu-Hsi Hsieh Chih-Chun Tsai Chih-Wei Tseng Kuo-Chih Tseng

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제10권 제5호

발행연도: 2016.1

수록면: 803 - 807 (5page)

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연구주제

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연구배경

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연구방법

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Background/Aims: Spontaneous bacterial peritonitis (SBP) contributes to poorer short-term mortality in cirrhotic patients with ascites. However, it is unknown how long the effect of the first SBP event persists in these patients. Methods: The National Health Insurance Database, derived from the Taiwan National Health Insurance Program, was used to identify and enroll 7,892 cirrhotic patients with ascites who were hospitalized between January 1 and December 31, 2007. All patients were free from episodes of SBP from 1996 to 2006. Results: The study included 1,176 patients with SBP. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in this group were 21.8%, 38.9%, 57.5%, and 73.4%, respectively. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in the non-SBP group were 15.7%, 32.5%, 53.3%, and 72.5%, respectively. After adjusting for gender, age, and other medical comorbidities, the adjusted hazard ratios of SBP for 30-day, 30- to 90-day, 90-day to 1-year, and 1- to 3-year mortality were 1.49 (95% confidence interval [CI], 1.30 to 1.71), 1.19 (95% CI, 1.02 to 1.38), 1.04 (95% CI, 0.90 to 1.20), and 0.90 (95% CI, 0.77 to 1.05), respectively, compared with the non-SBP group. Conclusions: The effect of SBP on the mortality of cirrhotic patients with ascites disappeared in those surviving more than 90 days after the first SBP event.

#Cirrhosis #Spontaneous bacterial peritonitis #Ascites #Mortality

참고문헌 (25)

참고문헌 신청

Tandon P / 2011 / Renal dysfunction is the most important independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis / Clin Gastroenterol Hepatol 9:260~265

Christou L / 2007 / Bacterial infection-related morbidity and mortality in cirrhosis / Am J Gastroenterol 102:1510~1517

Follo A / 1994 / Renal impairment after spontaneous bacterial peritonitis in cirrhosis: incidence, clinical course, predictive factors and prognosis / Hepatology 20:1495~1501

Perdomo Coral G / 2003 / Renal impairment after spontaneous bacterial peritonitis: incidence and prognosis / Can J Gastroenterol 17:187~190

Wu CY / 2009 / Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease / Gastroenterology 137(e2):1641~1648

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