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논문 기본 정보

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Priyanka Jain (Department of Clinical Research Institute of Liver and Biliary Sciences) Saggere Muralikrishna Shasthry (Department of Hepatology and Liver Transplantation Institute of Liver and Biliary Sciences) Ashok Kumar Choudhury (Department of Hepatology Institute of Liver and Biliary Sciences) Rakhi Maiwall (Department of Hepatology and Liver Transplantation Institute of Liver and Biliary Sciences) Guresh Kumar (Department of Clinical Research Institute of Liver and Biliary Sciences) Ankit Bharadwaj (Department of Clinical Research Institute of Liver and Biliary Sciences) Vinod Arora (Department of Hepatology Institute of Liver and Biliary Sciences) Rajan Vijayaraghavan (Department of Hepatology Institute of Liver and Biliary Sciences) Ankur Jindal (Department of Hepatology and Liver Transplantation Institute of Liver and Biliary Sciences) Manoj Kumar Sharma (Department of Hepatology and Liver Transplantation Institute of Liver and Biliary Sciences) Vikram Bhatia (Department of Hepatology Institute of Liver and Biliary Sciences) Shiv Kumar Sarin (Department of Hepatology and Liver Transplantation Institute of Liver and Biliary Sciences)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제1호
발행연도
2021.1
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175 - 185 (11page)

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Background/Aims: Liver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC. Methods: Cirrhosis patients at index hospitalisation (from January 2010 to June 2017), with ≥1 year follow-up were included. Results: Five thousand and one hundred thirty-eight cirrhosis patients (age, 49.8±14.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2?10). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459/2,316). ALC compared to non-ALC were more often (P<0.001) male (97.7% vs. 67.7%), younger (40?50 group, 36.2% vs. 20.2%; P<0.001) with higher liver related complications at baseline, (P<0.001 for each), sepsis: 20.3% vs. 14.9%; ascites: 82.2% vs. 65.9%; spontaneous bacterial peritonitis: 21.8% vs. 15.7%; hepatic encephalopathy: 41.0% vs. 25.0%; acute variceal bleeding: 32.0% vs. 23.7%; and acute kidney injury 30.5% vs. 19.6%. ALC patients had higher Child-Pugh (10.6±2.0 vs. 9.0±2.3), model for end-stage liver-disease scores (21.49±8.47 vs. 16.85±7.79), and higher mortality (42.3% vs. 27.3%, P<0.001) compared to non-ALC. Conclusions: One-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age.
#Cirrhosis #Ascites #Bleeding #Morbidity #Mortality

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참고문헌 (32)

참고문헌 신청
Sarin SK / Global burden of liver disease: a true burden on health sciences and economies google schola Lim YS / 2008 / The global impact of hepatic fibrosis and endstage liver disease / Clin Liver Dis 12:733~746 google schola Scaglione S / 2015 / The epidemiology of cirrhosis in the United States: a populationbased study / J Clin Gastroenterol 49:690~696 google schola GBD 2017 Cirrhosis Collaborators / 2020 / The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 / Lancet Gastroenterol Hepatol 5:245~266 google schola Mokdad AA / 2014 / Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis / BMC Med 12:145 google schola

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