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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 370 - 380 (11page)
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초록· 키워드
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Background/Aims: This study investigated the expression of T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3), human β-defensin (HBD)-2, forkhead box protein 3 (FOXP3), and the frequency of CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in children with Crohn’s disease (CD) during infliximab therapy. Methods: We enrolled 20 CD patients who received infliximab treatment for 1 year. Peripheral blood and colonic mucosal specimens were collected from all CD patients and from healthy control individuals. Results: A significant difference in TIM-3 mRNA expression was evident in peripheral blood mononuclear cells and colonic mucosa between CD patients before infliximab therapy and the healthy controls (p<0.001 and p=0.005, respectively). A significant difference in HBD-2 mRNA expression was found in colonic mucosa between CD patients before infliximab therapy and the healthy controls (p=0.013). In the active phase of CD, at baseline, the median percentage of T cells that were CD25+ FOXP3+ was 1.5% (range, 0.32% to 3.49%), which increased after inflixmab treatment for 1 year to 2.2% (range, 0.54% to 5.02%) (p=0.008). Conclusions: Our study suggests that both the adaptive and innate immune systems are closely linked to each other in CD pathogenesis. And the results of our study indicate that it could be a useful therapeutic tool, where restoration of TIM-3, HBD-2 and the function of Tregs may repair the dysfunctional immunoregulation in CD.
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참고문헌 (48)
참고문헌 신청
IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition / 2005 / Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria / J Pediatr Gastroenterol Nutr 41:1~7
Hyams JS / 1991 / Development and validation of a pediatric Crohn’s disease activity index / J Pediatr Gastroenterol Nutr 12:439~447
Allen JE / 1997 / Th1-Th2: reliable paradigm or dangerous dogma? / Immunol Today 18:387~392
Rook G / 2001 / Th1- or Th2-cell commitment during infectious disease: an oversimplification? / Trends Immunol 22:481~482
Anderson DE / 2007 / TIM-3 as a therapeutic target in human inflammatory diseases / Expert Opin Ther Targets 11:1005~1009
Hyams JS / 1991 / Development and validation of a pediatric Crohn’s disease activity index / J Pediatr Gastroenterol Nutr 12:439~447
Allen JE / 1997 / Th1-Th2: reliable paradigm or dangerous dogma? / Immunol Today 18:387~392
Rook G / 2001 / Th1- or Th2-cell commitment during infectious disease: an oversimplification? / Trends Immunol 22:481~482
Anderson DE / 2007 / TIM-3 as a therapeutic target in human inflammatory diseases / Expert Opin Ther Targets 11:1005~1009
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