Towards the Application of Human Defensins as Antivirals

Park, Mee Sook; Kim, Jin Il; Lee, Ilseob; Park, Sehee; Bae, Joon-Yong; Park, Man-Seong

추천

검색

자료유형: 학술저널

저자정보: Park, Mee Sook (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University) Kim, Jin Il (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University) Lee, Ilseob (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University) Park, Sehee (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University) Bae, Joon-Yong (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University) Park, Man-Seong (Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제26권 제3호

발행연도: 2018.1

수록면: 242 - 254 (13page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express ${\alpha}$- and ${\beta}$-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the 'defensin vaccine' concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

#Adjuvant #Antiviral #Defensin #Prophylactic #Therapeutic #Virus

참고문헌 (170)

참고문헌 신청

Albanesi, C. / 2007 / IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3 / J. Immunol. 179:984~992

Alen, M. M. / 2012 / Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection / Antiviral Res. 96:280~287

Antcheva, N. / 2009 / Artificial beta-defensin based on a minimal defensin template / Biochem. J. 421:435~447

Bastian, A. / 2001 / Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro / Regul. Pept. 101:157~161

Biragyn, A. / 2002 / Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2 / Science 298:1025~1029

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!