지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 197 - 204 (8page)
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Background/Aims: Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea. Methods: This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of ＞ 250 cells/mm3 in the absence of data compatible with secondary peritonitis. Results: The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%): Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-generation cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum β-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality.
Conclusions: SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Berg RD / 1999 / Bacterial translocation from the gastrointestinal tract / Adv Exp Med Biol 473 : 11 ~ 30
Cirera I / 2001 / Bacterial translocation of enteric organisms in patients with cirrhosis / J Hepatol 34 : 32 ~ 37
Conn HO / 1964 / Spontaneous peritonitis and bacteremia in Laennec's cirrhosis caused by enteric organisms: a relatively common but rarely recognized syndrome / Ann Intern M
De Fernandez MA / 1987 / Neutrophil phagocytic and bactericidal function in primary biliary cirrhosis and other chronic liver diseases / Clin Exp Immunol 67 : 655 ~ 661
Felisart J / 1985 / Cefotaxime is more effective than is ampicillin-tobramycin in cirrhotics with severe infections / Hepatology 5 : 457 ~ 462
Cirera I / 2001 / Bacterial translocation of enteric organisms in patients with cirrhosis / J Hepatol 34 : 32 ~ 37
Conn HO / 1964 / Spontaneous peritonitis and bacteremia in Laennec's cirrhosis caused by enteric organisms: a relatively common but rarely recognized syndrome / Ann Intern M
De Fernandez MA / 1987 / Neutrophil phagocytic and bactericidal function in primary biliary cirrhosis and other chronic liver diseases / Clin Exp Immunol 67 : 655 ~ 661
Felisart J / 1985 / Cefotaxime is more effective than is ampicillin-tobramycin in cirrhotics with severe infections / Hepatology 5 : 457 ~ 462
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