지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 953 - 959 (7page)
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초록· 키워드
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Purpose: Due to the seroepidemiological shift in hepatitis A (HA), its severity, mortality, and complications have increased in recent years. Thus, the aim of this study was to identify predictive factors associated with poor prognosis among patientswith HA. Materials and Methods: A total of 304 patients with HA admittedto our institution between July 2009 and June 2011 were enrolled consecutively. Patients with complications defined as acute liver failure (ALF) were evaluated, and mortality was defined as death or liver transplantation. Results: The mean age of patients (204 males, 100 females) was 32 years. Eighteen (5.9%) patients had progressed to ALF. Of the patients with ALF, 10 patients (3.3%) showed spontaneoussurvival while 8 (2.6%) died or underwent liver transplantation. Multivariate regression analysis showed that Model for End-Stage Liver Disease (MELD) and systemic inflammatory response syndrome (SIRS) scores were significant predictivefactors of ALF. Based on receiver operating characteristics (ROC) analysis, a MELD ≥23.5 was significantly more predictive than a SIRS score ≥3 (area under the ROC: 0.940 vs. 0.742, respectively). In addition, of patients with a MELD score ≥23.5, King’s College Hospital criteria (KCC) and SIRS scores were predictivefactors associated with death/transplantation in multivariate analysis. Conclusion:MELD and SIRS scores ≥23.5 and ≥3, respectively, appeared to be related to ALF development. In addition, KCC and SIRS scores ≥3 were valuable in predictingmortality of patients with a MELD ≥23.5.
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참고문헌 (26)
참고문헌 신청
Anand AC / 1997 / Early indicators of prognosis in fulminant hepatic failure: an assessment of the King’s criteria / J Hepatol 26 : 62 ~ 68
Corrao G / 1998 / Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis / Hepatology 27 : 914 ~ 9
Craig DG / 2011 / The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophe
Cuthbert JA / 2001 / Hepatitis A: old and new / Clin Microbiol Rev 14 : 38 ~ 58
England JM / 1974 / Red-cell-volume distribution curves and the measurement of anisocytosis / Lancet 1 : 701 ~ 703
Corrao G / 1998 / Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis / Hepatology 27 : 914 ~ 9
Craig DG / 2011 / The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophe
Cuthbert JA / 2001 / Hepatitis A: old and new / Clin Microbiol Rev 14 : 38 ~ 58
England JM / 1974 / Red-cell-volume distribution curves and the measurement of anisocytosis / Lancet 1 : 701 ~ 703
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