지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Purpose: Acute acetaminophen intoxication is a common occurrence that can cause lethal complications. In most domestic emergency departments, clinicians tend to treat acetaminophen intoxication based on patients’ history alone, simply due to the lack of a rapid acetaminophen laboratory test. We performed a 20-month study of intoxication patients to determine the correlation between the history of patients and serum laboratory tests for acetaminophen.
Methods: We took blood samples from 280 intoxication patients to evaluate whether laboratory findings detected traces of acetaminophen in the sample. Patients were then treated according to their history. Laboratory results came out after patients’discharge. Agreement between patients’ history and laboratory results were analyzed.
Results: Among the 280 intoxicated patients enrolled, 38 patients had positive serum acetaminophen concentrations; 18 out of 38 patients did not represent a history suggesting acetaminophen intoxication. One patient without the history showed toxic serum acetaminophen concentration. Among the patients with the history, two patients with toxic serum acetaminophen concentration did not receive N-acetylcysteine (NAC) treatment due to their low reported doses, while other 2 patients without significant serum acetaminophen concentration did receive NAC treatment due to their high reported doses.
Conclusion: This study showed a good overall agreement between history and laboratory test results. However, some cases showed inconsistencies between their history and laboratory test results. Therefore, in treating intoxication patients, a laboratory test of acetaminophen with rapid results should be available in most domestic emergency departments.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Ambre J / 1977 / Liver toxicity after acetaminophen ingestion. Inadequacy of the dose estimate as an index of risk / JAMA 238 (6) : 500 ~ 501
Bum J / 2011 / Extended blood drug concentrations in extended release formulated acetaminophen overdose patients / J Korean Soc Clin Toxicol 9 (2) : 71 ~ 76
Camilleri R / 2015 / A Meta-analysis of the reliability of the history in suspected poisoning / J Emerg Med 48 (6) : 679 ~ 684
Dargan PI / 2002 / Acetaminophen poisoning: an update for the intensivist / Crit Care 6 (2) : 108 ~
Dart RC / 2006 / Acetaminophen poisoning: an evidencebased consensus guideline for out-of-hospital management / Clin Toxicol Phila Pa 44 (1) : 1 ~ 18
Bum J / 2011 / Extended blood drug concentrations in extended release formulated acetaminophen overdose patients / J Korean Soc Clin Toxicol 9 (2) : 71 ~ 76
Camilleri R / 2015 / A Meta-analysis of the reliability of the history in suspected poisoning / J Emerg Med 48 (6) : 679 ~ 684
Dargan PI / 2002 / Acetaminophen poisoning: an update for the intensivist / Crit Care 6 (2) : 108 ~
Dart RC / 2006 / Acetaminophen poisoning: an evidencebased consensus guideline for out-of-hospital management / Clin Toxicol Phila Pa 44 (1) : 1 ~ 18
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