지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 293 - 301 (9page)
이용수
초록· 키워드
오류제보하기
Combination chemotherapy is more effective than mono-chemotherapy and is widely used in clinical practice for enhanced cancer treatment. In this study, we investigated the potential synergistic effects of acetaminophen, a common component in many cold medicines, and romidepsin, a histone deacetylase (HDAC) inhibitor, in the A549 non-small cell lung cancer (NSCLC) cell line. The combination of acetaminophen and romidepsin also exerted significant cytotoxicity and apoptosis induced by activation of caspase-3 on tumor cells in vitro. Moreover, combination therapy significantly induced increased production of chemokines that stimulate migration of activated T-cells into tumor cells. This mechanism can lead to active T-cell mediated anti-tumor immunity in addition to the direct cytotoxic chemotherapeutic effect. Activated T-cells led to enhanced cytotoxicity in drug-treated A549 cells through interaction with tumor cells. These results suggested that the interaction between the two drugs is synergistic and significant. In conclusion, our data showed that the use of romidepsin and low concentrations acetaminophen could induce effective anti-tumor effects via enhanced tumor immune and direct cytotoxic chemotherapeutic responses. The combination of acetaminophen with romidepsin should be considered as a promising strategy for the treatment of lung cancer.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Bayat Mokhtari R / 2017 / Combination therapy in combating cancer / Oncotarget 8:38022~38043
Bundscherer AC / 2018 / Acetaminophen and metamizole induce apoptosis in ht 29and sw 480 colon carcinoma cell lines in vitro / Anticancer Res 38:745~751
Gao M / 2014 / Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in jurkat t-leukemia cells / Acta Biochim Biophys Sin 46:484~491
Hopewell EL / 2013 / Lung tumor nf-κb signaling promotes t cell-mediated immune surveillance / The Journal of Clinical Investigation 123:2509~2522
Jozwiak-Bebenista M / 2014 / Paracetamol: Mechanism of action, applications and safety concern / Acta Pol Pharm 71:11~23
Bundscherer AC / 2018 / Acetaminophen and metamizole induce apoptosis in ht 29and sw 480 colon carcinoma cell lines in vitro / Anticancer Res 38:745~751
Gao M / 2014 / Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in jurkat t-leukemia cells / Acta Biochim Biophys Sin 46:484~491
Hopewell EL / 2013 / Lung tumor nf-κb signaling promotes t cell-mediated immune surveillance / The Journal of Clinical Investigation 123:2509~2522
Jozwiak-Bebenista M / 2014 / Paracetamol: Mechanism of action, applications and safety concern / Acta Pol Pharm 71:11~23
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UCI(KEPA) : I410-ECN-0101-2020-510-000238638