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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 218 - 231 (14page)
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초록· 키워드
오류제보하기
Background: We recently reported that Salvia plebeia R. Br. extracts suppress leukotriene production and effectively inhibit the airway inflammatory response by modulating inflammatory chemokine and cytokine expression. Here, we investigated the synergistic airway anti-inflammation effect of Salvia plebeia and Panax ginseng (Korean red ginseng, KRG) that has been used to treat various immune diseases such as asthma.
Methods and Results: To evaluate the synergistic airway anti-inflammatory effect of Salvia plebeia and KRG, we measured the inhibitory effect of monotheraphy with either or co-theraphy with both on leukotriene and reactive oxygen species (ROS) production. Using coal a combustion, fly ash, and diesel exhaust particle (CFD)-induced respiratory disease mouse model, we found that co-theraphy synergistically suppressed airway inflammatory signs such as alveolar wall thickness and collagen fibers deposition, and decreased the number of total cell, CD11b+Gr-1+ cells, and inflammatory cytokines (IL17A, TNF, MIP-2 and CXCL-1) in bronchoalveolar lavage (BAL) fluid.
Conclusions: We confirmed respiratory protection as a therapeutic effect of the Salbia plebeia-KRG 3 : 1 complex (KGC-03-PS) via anti-tracheal muscle contraction and expectorant animal studies using a CFD-induced respiratory disease mouse model.
Methods and Results: To evaluate the synergistic airway anti-inflammatory effect of Salvia plebeia and KRG, we measured the inhibitory effect of monotheraphy with either or co-theraphy with both on leukotriene and reactive oxygen species (ROS) production. Using coal a combustion, fly ash, and diesel exhaust particle (CFD)-induced respiratory disease mouse model, we found that co-theraphy synergistically suppressed airway inflammatory signs such as alveolar wall thickness and collagen fibers deposition, and decreased the number of total cell, CD11b+Gr-1+ cells, and inflammatory cytokines (IL17A, TNF, MIP-2 and CXCL-1) in bronchoalveolar lavage (BAL) fluid.
Conclusions: We confirmed respiratory protection as a therapeutic effect of the Salbia plebeia-KRG 3 : 1 complex (KGC-03-PS) via anti-tracheal muscle contraction and expectorant animal studies using a CFD-induced respiratory disease mouse model.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (36)
참고문헌 신청
Akiyama K. / 2006 / Gas chromatographic analysis and aerosol mass spectrometer measurement of diesel exhaust particles composition / Talanta 70:178~181
Bae KC / 1998 / Antioxidant effects of Korea ginseng radix, Korean red ginseng radix and total saponin / Korean Journal Oriental Medical Pathology 12:72~81
Barnes PJ. / 1994 / Cytokines as mediators of chronic asthma / American Journal of Respiratory and Critical Care Medicine 150:42~49
Bohadana AB / 2000 / Symptoms, airway responsiveness, and exposure to dust in beech and oak wood workers / Occupational and Environmental Medicine 57:268~273
Brandt EB / 2013 / Diesel exhaust particle induction of IL-17A contributes to severe asthma / Journal of Allergy and Clinical Immunology 132:1194~1204
Bae KC / 1998 / Antioxidant effects of Korea ginseng radix, Korean red ginseng radix and total saponin / Korean Journal Oriental Medical Pathology 12:72~81
Barnes PJ. / 1994 / Cytokines as mediators of chronic asthma / American Journal of Respiratory and Critical Care Medicine 150:42~49
Bohadana AB / 2000 / Symptoms, airway responsiveness, and exposure to dust in beech and oak wood workers / Occupational and Environmental Medicine 57:268~273
Brandt EB / 2013 / Diesel exhaust particle induction of IL-17A contributes to severe asthma / Journal of Allergy and Clinical Immunology 132:1194~1204
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UCI(KEPA) : I410-ECN-0101-2019-480-000930948