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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 143 - 150 (8page)
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초록· 키워드
오류제보하기
Background: Skin is an organ that protects the human body from various environmental stimuli that can induce immune system activation. Skin aging can be largely divided into two categories: physiological aging, which is caused by the a decreased physiological function of the skin and structural changes with aging, and photoaging, which is caused by the chemical stress induced by external stimuli such as ultraviolet (UV) radiation.
Methods and Results: The objective of this study was to investigate the anti-wrinkle and UV protective effect of catechin-rich green tea extract (CGTE) in activated keratinocyte (HaCaT cells) and UV-induced skin damage in hairless mice. The results showed that CGTE inhibits the tumor necrosis factor-alpha interferon-gamma (TNF-α + IFN-γ)-induced expression of matrix metalloproteinase (MMP)-1 in HaCaT cells. In addition, the CGTE treatment significantly reduced wrinkle formation, epidermal thickness, collagen deposition, and transepidermal water loss in dorsal skin irradiated with UVB. However, the β-glucosidase activity was significantly increased. The CGTE treatment inhibits mRNA expression and enzyme activity of MMP-2 and MMP-9 in the dorsal skin irradiated with UVB.
Conclusions: It is expected that CGTE can be effectively used as a functional food and cosmetic ingredient to improve skin moisture retention and reduce wrinkle formation.
Methods and Results: The objective of this study was to investigate the anti-wrinkle and UV protective effect of catechin-rich green tea extract (CGTE) in activated keratinocyte (HaCaT cells) and UV-induced skin damage in hairless mice. The results showed that CGTE inhibits the tumor necrosis factor-alpha interferon-gamma (TNF-α + IFN-γ)-induced expression of matrix metalloproteinase (MMP)-1 in HaCaT cells. In addition, the CGTE treatment significantly reduced wrinkle formation, epidermal thickness, collagen deposition, and transepidermal water loss in dorsal skin irradiated with UVB. However, the β-glucosidase activity was significantly increased. The CGTE treatment inhibits mRNA expression and enzyme activity of MMP-2 and MMP-9 in the dorsal skin irradiated with UVB.
Conclusions: It is expected that CGTE can be effectively used as a functional food and cosmetic ingredient to improve skin moisture retention and reduce wrinkle formation.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHOD
RESULTS AND DISCUSSIONS
REFERENCES
참고문헌 (19)
참고문헌 신청
Berardesca E / 1990 / Transepidermal water loss and skin surface hydration in the non invasive assessment of stratum corneum function. Dermatosen in Beruf und Umwelt / Occupation and Environment 38:50~53
Boelsma E / 2001 / Nutritional skin care: Health effects of micronutrients and fatty acids / American Journal of Clinical Nutrition 73:853~864
Cabrera C / 2006 / Beneficial effects of green tea-a review / Journal of the American College of Nutrition 25:79~99
Chen ZP / 1998 / Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts / Cancer Letters 129:173~179
Choi SW / 2014 / Mass production of highly pure epigallocatechin gallate / Korea. Patents. 1016594230000
Boelsma E / 2001 / Nutritional skin care: Health effects of micronutrients and fatty acids / American Journal of Clinical Nutrition 73:853~864
Cabrera C / 2006 / Beneficial effects of green tea-a review / Journal of the American College of Nutrition 25:79~99
Chen ZP / 1998 / Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts / Cancer Letters 129:173~179
Choi SW / 2014 / Mass production of highly pure epigallocatechin gallate / Korea. Patents. 1016594230000
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UCI(KEPA) : I410-ECN-0101-2019-480-000803840