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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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This study examined the effect of 3,4-dihydroxytoluene (DHT) on UVB-induced photoaging and determined its molecular mechanisms, using HaCaT human keratinocytes and SKH-1 hairless mice. DHT suppressed UVB-induced matrix metalloproteinase-1 (MMP-1) expression in HaCaT cells. In vivo data from mouse skin supported that DHT decreased UVBinduced wrinkle formation, epidermal thickness, and matrix metalloproteinase-13 (MMP-13) expression. DHT appeared to exert its anti-aging effects by suppressing UVB-induced Raf-1 kinase activity and subsequent attenuation of UVB-induced phosphorylation of MEK, ERK, and p90RSK in HaCaT cells. In vitro and in vivo pull-down assays revealed that DHT bound with Raf-1 in ATP-noncompetitive manner. Overall, DHT appears to anti-photoaging effects in vitro and in vivo through the suppression of Raf-1 kinase activity and may have potential as a treatment for the prevention of skin aging.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (55)
참고문헌 신청
Afaq F, Adhami VM, Mukhtar H. Photochemoprevention of ultraviolet b signaling and photocarcinogenesis. Mutat. Res. 571: 153-173 (2005)
Arjumand W, Seth A, Sultana S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing nfkappab, tnf-alpha and caspase-3 expression in wistar rats. Food Chem. Toxicol. 49: 2013-2021 (2011)
Baba S, Furuta T, Horie M, Nakagawa H. Studies on drug metabolism by use of isotopes xxvi: Determination of urinary metabolites of rutin in humans. J. Pharm. Sci. 70: 780-782 (1981)
Berneburg M, Plettenberg H, Krutmann J. Photoaging of human skin. Photodermatol. Photoimmunol. Photomed. 16: 239-244 (2000)
Bhattacharyya TK, Pathria M, Mathison C, Vargas M, Thomas JR. Cosmeceutical effect on skin surface profiles and epidermis in uv-b-irradiated mice. JAMA Facial Plast. Surg. 16: 253-260 (2014)
Arjumand W, Seth A, Sultana S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing nfkappab, tnf-alpha and caspase-3 expression in wistar rats. Food Chem. Toxicol. 49: 2013-2021 (2011)
Baba S, Furuta T, Horie M, Nakagawa H. Studies on drug metabolism by use of isotopes xxvi: Determination of urinary metabolites of rutin in humans. J. Pharm. Sci. 70: 780-782 (1981)
Berneburg M, Plettenberg H, Krutmann J. Photoaging of human skin. Photodermatol. Photoimmunol. Photomed. 16: 239-244 (2000)
Bhattacharyya TK, Pathria M, Mathison C, Vargas M, Thomas JR. Cosmeceutical effect on skin surface profiles and epidermis in uv-b-irradiated mice. JAMA Facial Plast. Surg. 16: 253-260 (2014)
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UCI(KEPA) : I410-ECN-0101-2020-594-001159394