지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.2
- 수록면
- 64 - 69 (6page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Alzheimer’s disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein (Aβ) in the brain may be closely correlated with the development of Alzheimer’s disease. In this study, the effects of an adzuki bean extract on the aggregation of Aβ were examined; moreover, the anti-Alzheimer’s activity of the adzuki extract was examined.
MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on Aβ<SUB>42</SUB> aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer’s disease in vivo, Aβ42-overexpressing Drosophila were used. In these flies, overexpression of Aβ<SUB>42</SUB> induced the formation of Aβ42 aggregates in the brain, decreased motor function, and resulted in cognitive impairment.
RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of Aβ42 aggregates in a concentration-dependent manner. When Aβ<SUB>42</SUB>-overexpressing flies were fed regular medium containing adzuki extract, the Aβ<SUB>42</SUB> level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in Aβ<SUB>42</SUB>-overexpressing flies fed regular medium with adzuki extract.
CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer’s disease and provide useful information for identifying novel prevention treatments for Alzheimer’s disease.
MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on Aβ<SUB>42</SUB> aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer’s disease in vivo, Aβ42-overexpressing Drosophila were used. In these flies, overexpression of Aβ<SUB>42</SUB> induced the formation of Aβ42 aggregates in the brain, decreased motor function, and resulted in cognitive impairment.
RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of Aβ42 aggregates in a concentration-dependent manner. When Aβ<SUB>42</SUB>-overexpressing flies were fed regular medium containing adzuki extract, the Aβ<SUB>42</SUB> level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in Aβ<SUB>42</SUB>-overexpressing flies fed regular medium with adzuki extract.
CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer’s disease and provide useful information for identifying novel prevention treatments for Alzheimer’s disease.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer’s disease
Nutrition Research and Practice
2019 .02
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Protective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2022 .04
-
Protective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2022 .04
-
Protective role of caffeic acid in an Aβ25-35-induced Alzheimer’s disease model
Nutrition Research and Practice
2015 .10
-
Protective role of caffeic acid in an Aβ25-35-induced Alzheimer’s disease model
Nutrition Research and Practice
2015 .10
-
Transfer of a Healthy Microbiota Reduces Amyloid and Tau Pathology in an Alzheimer’s Disease Animal Model
한국미생물학회 학술대회논문집
2020 .10
-
Perilla frutescens var. japonica and rosmarinic acid improve amyloid-β25-35 induced impairment of cognition and memory function
Nutrition Research and Practice
2016 .06
-
Perilla frutescens var. japonica and rosmarinic acid improve amyloid-β25-35 induced impairment of cognition and memory function
Nutrition Research and Practice
2016 .06
-
Stem Rot on Adzuki Bean (Vigna angularis) Caused by Rhizoctonia solani AG 4HGI in China
The Plant Pathology Journal
2015 .03
-
한국 노인의 식생활 지침 실천도와 알츠하이머형 치매의 관련성
Journal of Nutrition and Health
2015 .06
-
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
극지연구소 초록집
2022 .09
-
Ceria nanoparticles targeted to mitochondria as antioxidants for alzheimer’s disease
한국진공학회 학술발표회초록집
2016 .08
-
Manufacture and characterization of natural shade cosmetics using bean extract
한국분석과학회 학술대회
2019 .11
-
Effects of Newly Synthesized Recombinant Human Amyloid-β Complexes and Poly-Amyloid-β Fibers on Cell Apoptosis and Cognitive Decline
Journal of Microbiology and Biotechnology
2017 .01
-
Highly ordered and disposable nanopillar array for detection of beta-amyloid
한국진공학회 학술발표회초록집
2021 .02
-
Optimization of Ultrasound-Assisted Pretreatment for Accelerating Rehydration of Adzuki Bean ( Vigna angularis )
Journal of Microbiology and Biotechnology
2024 .04
-
Brain segmentation analysis using brain magnetic resonance imaging (MRI) measurements for comparison between normal controls and Alzheimer’s disease (AD) patients
한국자기학회 학술연구발표회 논문개요집
2020 .07
-
Manufacture and characterization of mascara using coffee bean extract
한국분석과학회 학술대회
2018 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-594-000439665