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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.45 No.4
- 발행연도
- 2018.12
- 수록면
- 769 - 777 (9page)
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초록· 키워드
오류제보하기
The fermentation of Panax ginseng yields many compounds including ginsenosides that have various biological functions. The objective of this study was to investigate the modulation of nitric oxide (NO), Interleukin (IL)-6 and tumor necrosis factor (TNF)-α in Raw 264.7 cells treated with ginseng fermented by Penibacillus MBT213. Nitric oxide production in the Raw 264.7 cells treated for 24 hours with fermented ginseng at 3, 7, and 14 days after the treatment decreased to 74, 43, and 36%, respectively, compared with the positive control. The production of IL-6 was inhibited in all the cells treated with fermented ginseng at 3, 7, and 14 days after the treatment except for the positive control. The TNF-α production in the Raw 264.7 cells treated with fermented ginseng for 6 hours at 3, 7, and 14 days after the treatment was about 40,000, 85,000 and 65,000 pg/mL, respectively. Moreover, the TNF-α production in the Raw 264.7 cells treated with fermented ginseng for 24 hours at 7 and 14 days after the treatment was about 160,000 and 180,000 pg/mL, respectively. However, TNF-α production was inhibited in the Raw 264.7 cells at 6 and 12 hours after the treatment with fermented ginseng. herefore, it was confirmed that the immunological activity of the Raw 264.7 macrophages was affected by the treatment with fermented ginseng. It was concluded that ginseng fermented by Paenibacillus MBT213 possesses a potential anti-inflammatory activity and could be used as an ingredient in functional foods and pharmaceutical products.
목차
Abstract
Introduction
Materals and Methods
Results and Discussion
Conclusion
References
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Attele as / 1999 / Ginseng pharmacology : Multiple constituents and multiple actions / Biochemical Pharmacology 58 : 1685 ~ 1693
[학술지(정기간행물)] - Bae EA / 2002 / Metabolism of 20(S)and 20(R)ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities / Biological and Pharmaceutical Bulletin 25 : 58 ~ 63
[학술지(정기간행물)] - 김상찬 / 2005 / 현삼메탄올 추출물이 LPS로 유도된Raw 264.7 cell에서의 TNF-α, IL-1β, IL-6 및 nitric oxide 생성에 미치는 영향 / 대한본초학회지 20 (2) : 7 ~ 16
[학술지(정기간행물)] - Cheng LQ / 2006 / Conversion of major ginsenoside Rb(1)to ginsenoside F(2)by Caulobacter leidyia / Biotechnology Letters 28 : 1121 ~ 1127
[학술지(정기간행물)] - Cheng L-Q / 2008 / Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514 / Phytochemistry 69 : 218 ~ 224
[학술지(정기간행물)] - Bae EA / 2002 / Metabolism of 20(S)and 20(R)ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities / Biological and Pharmaceutical Bulletin 25 : 58 ~ 63
[학술지(정기간행물)] - 김상찬 / 2005 / 현삼메탄올 추출물이 LPS로 유도된Raw 264.7 cell에서의 TNF-α, IL-1β, IL-6 및 nitric oxide 생성에 미치는 영향 / 대한본초학회지 20 (2) : 7 ~ 16
[학술지(정기간행물)] - Cheng LQ / 2006 / Conversion of major ginsenoside Rb(1)to ginsenoside F(2)by Caulobacter leidyia / Biotechnology Letters 28 : 1121 ~ 1127
[학술지(정기간행물)] - Cheng L-Q / 2008 / Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514 / Phytochemistry 69 : 218 ~ 224
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UCI(KEPA) : I410-ECN-0101-2019-520-000313584