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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.45 No.4
- 발행연도
- 2018.12
- 수록면
- 707 - 713 (7page)
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초록· 키워드
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This study was done to search for positional candidate genes associated with the back fat thickness trait using a Genome-Wide Association Study (GWAS) in purebred Yorkshires (N = 1755). Genotype and phenotype analyses were done for 1,642 samples. As a result of the associations with back fat thickness using the Gemma program (ver. 0.93), when the genomewide suggestive threshold was determined using the Bonferroni method (p = 1.61 × 10<SUP>-5</SUP>), the single nucleotide polymorphism (SNP) markers with suggestive significance were identified in 1 SNP marker on chromosome 2 (MARC0053928; p = 3.65 × 10<SUP>-6</SUP>), 2 SNP markers on chromosome 14 (ALGA0083078; p = 7.85 × 10<SUP>-6</SUP>, INRA0048453; p = 1.27 × 10<SUP>-5</SUP>), and 1 SNP marker on chromosome 18 (ALGA0120564; p = 1.44 × 10<SUP>-5</SUP>). We could select positional candidate genes (KCNQ1, DOCK1, LOC106506151, and LOC110257583), located close to the SNP markers. Among these, we identified a potassium voltage-gated channel subfamily Q member gene (KCNQ1) and the dedicator of cytokinesis 1 (DOCK1) gene associated with obesity and Type-2 diabetes. The SNPs and haplotypes of the KCNQ1 and DOCK1 genes can contribute to understanding the genetic structure of back fat thickness. Additionally, it may provide basic data regarding marker assisted selection for a meat quality trait in pigs.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Benton MC / 2015 / An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss / Genome Biology 16
[학술지(정기간행물)] - Bland JM / 1995 / Multiple significance tests : The Bonferroni method / British Medical Journal 310 : 170 ~
[학술지(정기간행물)] - Borchers T / 1997 / Heart-type fatty acid binding protein-involvement in growth inhibition and differentiation / Prostaglandins Leukot Essent Fatty Acids 57 : 77 ~ 84
[학술지(정기간행물)] - Fontanesi L / 2009 / The porcine fat mass and obesity associated(FTO)gene is associated with fat deposition in italian duroc pigs / Animal Genetics 40 : 90 ~ 93
[학술지(정기간행물)] - Fujii J / 1991 / Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia / Science 253 : 448 ~ 451
[학술지(정기간행물)] - Bland JM / 1995 / Multiple significance tests : The Bonferroni method / British Medical Journal 310 : 170 ~
[학술지(정기간행물)] - Borchers T / 1997 / Heart-type fatty acid binding protein-involvement in growth inhibition and differentiation / Prostaglandins Leukot Essent Fatty Acids 57 : 77 ~ 84
[학술지(정기간행물)] - Fontanesi L / 2009 / The porcine fat mass and obesity associated(FTO)gene is associated with fat deposition in italian duroc pigs / Animal Genetics 40 : 90 ~ 93
[학술지(정기간행물)] - Fujii J / 1991 / Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia / Science 253 : 448 ~ 451
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UCI(KEPA) : I410-ECN-0101-2019-520-000313655