지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 76 - 82 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Lgr5 is a well-known stem cell marker in colorectal cancer (CRC). This retrospective study evaluated the expressions of Lgr5 in CRC specimens, and examined whether these expressions were associated with survival outcomes.
Methods: We used immunohistochemistry to retrospectively examine expressions of Lgr5 in paraffin-embedded specimens from 337 patients with CRC between January 2009 and December 2013. All clinicopathologic data were collected by retrospective review based on medical records. The correlation between its expression and clinicopathological data as well as clinical outcomes of patients was analyzed.
Results: Low expression and high expression of Lgr5 in 337 patients were 175 (51.9%) and 162 (48.1%), respectively. There was no statistically significant difference in the association of Lgr5 expression with clinicopathologic factors (age, tumor location, lymphatic invasion, vascular invasion, perineural invasion, TNM stage, and differentiation). In the survival analysis, the high expression group of Lgr5 showed a better prognosis than the low expression group in disease-free survival (P=0.044). However, overall survival was not significantly different between the two groups (P=0.087). In multivariate analysis, we found that high expression of Lgr5 was independent prognostic factor for tumor relapse (hazard ratio, 0.601; 95% confidence interval, 0.388–0.929; P=0.022).
Conclusion: In present study, high expression of Lgr5 is an independent predictor of favorable prognosis in patients with CRC. So, further well designed, prospective, large scale studies are needed to examine the value of Lgr5 as a prognostic biomarker for CRC.
Methods: We used immunohistochemistry to retrospectively examine expressions of Lgr5 in paraffin-embedded specimens from 337 patients with CRC between January 2009 and December 2013. All clinicopathologic data were collected by retrospective review based on medical records. The correlation between its expression and clinicopathological data as well as clinical outcomes of patients was analyzed.
Results: Low expression and high expression of Lgr5 in 337 patients were 175 (51.9%) and 162 (48.1%), respectively. There was no statistically significant difference in the association of Lgr5 expression with clinicopathologic factors (age, tumor location, lymphatic invasion, vascular invasion, perineural invasion, TNM stage, and differentiation). In the survival analysis, the high expression group of Lgr5 showed a better prognosis than the low expression group in disease-free survival (P=0.044). However, overall survival was not significantly different between the two groups (P=0.087). In multivariate analysis, we found that high expression of Lgr5 was independent prognostic factor for tumor relapse (hazard ratio, 0.601; 95% confidence interval, 0.388–0.929; P=0.022).
Conclusion: In present study, high expression of Lgr5 is an independent predictor of favorable prognosis in patients with CRC. So, further well designed, prospective, large scale studies are needed to examine the value of Lgr5 as a prognostic biomarker for CRC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68 : 394 ~ 424
[인터넷자원] - National Cancer Information Center / / Caner statistics
[학술지(정기간행물)] - 정규원 / 2017 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014 / Cancer Research and Treatment 49 (2) : 292 ~ 305
[학술지(정기간행물)] - Siegel RL / 2018 / Cancer statistics / CA Cancer J Clin 68 : 7 ~ 30
[학술지(정기간행물)] - Ricci-Vitiani L / 2007 / Identification and expansion of human colon-cancer-initiating cells / Nature 445 : 111 ~ 115
[인터넷자원] - National Cancer Information Center / / Caner statistics
[학술지(정기간행물)] - 정규원 / 2017 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014 / Cancer Research and Treatment 49 (2) : 292 ~ 305
[학술지(정기간행물)] - Siegel RL / 2018 / Cancer statistics / CA Cancer J Clin 68 : 7 ~ 30
[학술지(정기간행물)] - Ricci-Vitiani L / 2007 / Identification and expansion of human colon-cancer-initiating cells / Nature 445 : 111 ~ 115
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker
대한암예방학회지
2016 .01
-
Increased Immunoreactivity of LGR4 in Histologically Aggressive Basal Cell Carcinoma
Annals of Dermatology
2018 .01
-
Lineage tracing of Lrig1- and Lgr5-positive cells as stem cell marker
한국실험동물학회 학술발표대회 논문집
2016 .02
-
LGR5 regulates muscle development in the soft palate through WNT/beta-catenin signaling
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Aberrant Expression of Markers of Cancer Stem Cells in Gastric Adenocarcinoma and their Relationship to Vasculogenic Mimicry
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain
한국실험동물학회 학술발표대회 논문집
2022 .01
-
FSP-1 expression in cancer cells is relevant to long-term oncological outcomes in nonmetastatic colorectal cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2022 .12
-
Clinicopathologic Characteristics of Young-Onset Colorectal Cancer
대한임상종양학회 학술대회지
2021 .06
-
Clinicopathologic characteristics of early-onset colorectal cancer
Annals of Coloproctology
2022 .10
-
Novel biomarkers for the diagnosis and prognosis of colorectal cancer
Intestinal research
2020 .01
-
[Colorectal] Prognostic Impact of Lymphovascular Invasion and Perineural Invasion in Colorectal Cancer: A Multicenter Study
대한외과학회 학술대회 초록집
2021 .11
-
Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer
Annals of Coloproctology
2022 .06
-
Factors Affecting Survival in Patients with Colorectal Cancer in Shiraz, Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
Journal of Pathology and Translational Medicine
2021 .01
-
Immunohistochemical Detection of p53 Expression in Patients with Preoperative Chemoradiation for Rectal Cancer: Association with Prognosis
Yonsei Medical Journal
2015 .01
-
Increased Expression of Thymosin β4 Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer
Journal of Pathology and Translational Medicine
2017 .01
-
CD9 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Lobular Carcinoma
Journal of Breast Cancer
2019 .01
-
Survival Analysis and Prognostic Factors for Colorectal Cancer Patients in Malaysia
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
Journal of Pathology and Translational Medicine
2019 .01
-
Survival of Colorectal Cancer in the Presence of Competing-Risks - Modeling by Weibull Distribution
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-514-000326867