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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제1호
- 발행연도
- 2017.1
- 수록면
- 9 - 16 (8page)
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Background: Thymosin β4 is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin β4 expression in human colorectal cancers (CRCs). Methods: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin β4 expression in association with hypoxia inducible factor-1α (HIF-1α) expression in the CRC series. Results: High expression of thymosin β4 was significantly correlated with lymphovascular invasion, invasion depth, regional lymph node metastasis, distant metastasis, and TNM stage. Patients with high expression of thymosin β4 showed poor recurrence-free survival (p = .001) and poor overall survival (p = .005) on multivariate analysis. We also found that thymosin β4 and HIF-1α were overexpressed and that thymosin β4 expression increased in parallel with HIF-1α expression in CRC. Conclusions: A high expression level of thymosin β4 indicates poor clinical outcomes and may be a useful prognostic factor in CRC. Thymosin β4 is functionally related with HIF-1α and may be a potentially valuable biomarker and possible therapeutic target for CRC.
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참고문헌 (22)
참고문헌 신청
Bristow RG / 2008 / Hypoxia and metabolism: hypoxia, DNA repair and genetic instability / Nat Rev Cancer 8 : 180 ~ 192
Cannito S / 2008 / Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells / Carcinogenesis 29 : 2267 ~ 2278
Clark EA / 2000 / Genomic analysis of metastasis reveals an essential role for RhoC / Nature 406 : 532 ~ 535
Giles RH / 2006 / Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis / Oncogene 25 : 3065 ~ 3070
Hsiao HL / 2006 / Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via
Cannito S / 2008 / Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells / Carcinogenesis 29 : 2267 ~ 2278
Clark EA / 2000 / Genomic analysis of metastasis reveals an essential role for RhoC / Nature 406 : 532 ~ 535
Giles RH / 2006 / Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis / Oncogene 25 : 3065 ~ 3070
Hsiao HL / 2006 / Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via
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