Aberrant Expression of Markers of Cancer Stem Cells in Gastric Adenocarcinoma and their Relationship to Vasculogenic Mimicry

Zhou, Lei; Yu, Lan; Feng, Zhen-Zhong; Gong, Xiao-Meng; Cheng, Ze-Nong; Yao, Nan; Wang, Dan-Na; Wu, Shi-Wu

추천

검색

자료유형: 학술저널

저자정보: Zhou, Lei (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Yu, Lan (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Feng, Zhen-Zhong (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Gong, Xiao-Meng (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Cheng, Ze-Nong (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Yao, Nan (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Wang, Dan-Na (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College) Wu, Shi-Wu (Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,177 - 4,183 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Gastric cancer is the second leading cause of cancer-related death in Asia, and the majority type is gastric adenocarcinoma (GAC). Most GAC patients die of recurrence and metastasis. Cancer stem cells (CSCs) have been thought to be responsible for the initiation, development, metastasis, and ultimately recurrence of cancer. In this study, we aimed to investigate expression and clinical significance of CSCs markers, CD133 and Lgr5, and vasculogenic mimicry (VM) in primary GAC. Materials and Methods: Specimens from 261 Chinese patients with follow-up were analyzed for CD133, Lgr5 protein expression and VM by immunohistochemical and histochemical staining. The Pearson Chi's square test was used to assess the associations among the positive staining of these markers and clinicopathological characteristics. Postoperative overall survival time was were studied by univariate and multivariate analyses. Results: In GAC tissues, positive rates of 49.0%, 38.7%, and 26.8% were obtained for CD133, Lgr5, and VM, respectively. The mean score of microvessel density (MVD) was $21.7{\pm}11.1$ in GAC tissues. There was a significantly difference between the positive and negative groups. There was a positive relationship between the VM, the expression of CD133 and Lgr5, and the score of MVD and the grades of tumor, lymph node metastasis, TNM stages (all p<0.05). The overall mean survival time of the patients with CD133, Lgr5, VM, and MVD (${\geq}22$) positive expression was lower than that of patients with negative expression. The score of MVD, positive expression of CD133 and VM were independent prognostic factors of GAC (p<0.05). Conclusions: VM, and expression of CD133, Lgr5, and the score of MVD are related to grades of tumor, lymph node metastasis, TNM stages, and overall mean survival time. It is suggested that CSCs and VM could play an important role in the evolution of GAC.

#Gastric neoplasm #CD133 #Lgr5 #VM #MVD #CSCs

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!