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논문 기본 정보

자료유형
학술저널
저자정보
Sou Hirose (The Jikei University Kashiwa Hospital Kashiwa Japan) Hiroshi Tanabe (The Jikei University Kashiwa Hospital Kashiwa Japan) Youko Nagayoshi (The Jikei University School of Medicine Tokyo Japan) Yukihiro Hirata (The Jikei University Katsushika Medical Center Tokyo Japan) Chikage Narui (The Jikei University Daisan Hospital Tokyo Japan) Kazuhiko Ochiai (The Jikei University Katsushika Medical Center Tokyo Japan) Seiji Isonishi (Jikei Daisan Hospital) Hirokuni Takano (The Jikei University Kashiwa Hospital Kashiwa Japan) Aikou Okamoto (The Jikei University School of Medicine)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.29 No.3
발행연도
2018.1
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1 - 11 (11page)

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Objective: The aim of the study is to investigate recurrence of stage I epithelial ovarian cancer. Methods: Six hundred two patients diagnosed with stage I epithelial ovarian cancer at 4 hospitals between 2000 and 2013 were retrospectively analyzed. Age, surgical procedure, substage, histologic type, adjuvant chemotherapy, recurrence, initial recurrence site (peritoneal dissemination [P], hematogenous recurrence [H], lymphogenous recurrence [L], and others [O]), and frequency of recurrence at each site were investigated retrospectively. Results: Median age was 54 years and median follow-up was 60 months. The stage was IA in 180 cases (30%), IB in 8 (1%), IC1 in 247 (41%), IC2 in 63 (10%), and IC3 in 104 (17%). Systematic lymph node dissection including both pelvic and para-aortic lymph nodes was performed in 224 patients (37%), and 412 patients (68%) received adjuvant chemotherapy. Recurrence occurred in 70 patients (11.6%). The median time to recurrence was 18 months, and the stage was IA in 13 (19%), IB in 1 (1%), IC1 in 24 (34%), IC2 in 9 (13%), and IC3 in 23 (33%) cases. The numbers of recurrence at the P, H, L, and O sites, including overlapping cases, were 49 (70%), 18 (26%), 9 (13%), and 6 (9%), respectively, and recurrence by peritoneal dissemination in the pelvis occurred in 43 cases (61%). Conclusion: Recurrence of stage I epithelial ovarian cancer by peritoneal dissemination was frequent, especially in the pelvis. There is a need to elucidate the pathogenesis of peritoneal recurrence and to prepare a treatment strategy to prevent pelvic peritoneal recurrence.

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