지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.96 No.3
- 발행연도
- 2019.3
- 수록면
- 116 - 122 (7page)
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초록· 키워드
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Purpose: The predictive role of obesity on pathologic complete response (pCR) after neoadjuvant chemoradiation (nCRT) in rectal cancer remains controversial. This study aimed to evaluate the association between obesity and pathologic response in patients with rectal cancer following nCRT.
Methods: A total of 320 patients with primary rectal cancer who underwent curative resection after nCRT between January 2010 and September 2014 were enrolled in this study. Obesity was defined as body mass index of ≥25 kg/m². Clinicopathologic characteristics were analyzed to identify independent predictive factors for pCR.
Results: Among the included patients, 23.4% (n = 75) were obese, and 14.7% (n = 47) showed pCR. Baseline characteristics were generally similar between obese and nonobese patients, except that women (P = 0.001) and cT2 tumors (P = 0.001) were more common in the obese group. Multivariate logistic regression analysis revealed that obesity (odds ratio [OR] = 2.051; 95% confidence interval [CI], 1.009-4.168), cT2 (OR, 3.614; 95% CI, 1.166-11.202), and pretreatment carcinoembryonic antigen <5 ng/mL (OR, 2.921; 95% CI, 1.365-6.253) were independent predictors for pCR. Obesity was not associated with disease-free survival or local recurrence-free survival.
Conclusion: Obesity was an independent predictive factor for pCR following nCRT in rectal cancer, but was not associated with recurrence. Further studies are needed to clarify the association between obesity and prognosis of rectal cancer after nCRT.
Methods: A total of 320 patients with primary rectal cancer who underwent curative resection after nCRT between January 2010 and September 2014 were enrolled in this study. Obesity was defined as body mass index of ≥25 kg/m². Clinicopathologic characteristics were analyzed to identify independent predictive factors for pCR.
Results: Among the included patients, 23.4% (n = 75) were obese, and 14.7% (n = 47) showed pCR. Baseline characteristics were generally similar between obese and nonobese patients, except that women (P = 0.001) and cT2 tumors (P = 0.001) were more common in the obese group. Multivariate logistic regression analysis revealed that obesity (odds ratio [OR] = 2.051; 95% confidence interval [CI], 1.009-4.168), cT2 (OR, 3.614; 95% CI, 1.166-11.202), and pretreatment carcinoembryonic antigen <5 ng/mL (OR, 2.921; 95% CI, 1.365-6.253) were independent predictors for pCR. Obesity was not associated with disease-free survival or local recurrence-free survival.
Conclusion: Obesity was an independent predictive factor for pCR following nCRT in rectal cancer, but was not associated with recurrence. Further studies are needed to clarify the association between obesity and prognosis of rectal cancer after nCRT.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
National Comprehensive Cancer Network / Rectal cancer clinical practice guidelines in oncology
Glimelius B / 2013 / Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup / Ann Oncol 24(Suppl 6):vi81~vi88
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
Gerard JP / 2004 / Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy : the lyon R96-02 randomized trial / J Clin Oncol 22:2404~2409
Martin ST / 2012 / Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer / Br J Surg 99:918~928
Glimelius B / 2013 / Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup / Ann Oncol 24(Suppl 6):vi81~vi88
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
Gerard JP / 2004 / Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy : the lyon R96-02 randomized trial / J Clin Oncol 22:2404~2409
Martin ST / 2012 / Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer / Br J Surg 99:918~928
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UCI(KEPA) : I410-ECN-0101-2019-514-000506738