지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 426 - 429 (4page)
이용수
초록· 키워드
오류제보하기
Chronic eosinophilic leukemia (CEL) is characterized by eosinophilia and organ damage. Imatinib is widely used for treating CEL, chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Unfortunately, the cancer cells gain resistance against the drug after prolonged molecular-targeted therapies. Imatinib-resistant EoL-1 (EoL-1-IR) cells were produced from chronic eosinophilic leukemia cells (EoL-1) after treatment with imatinib for a long duration. Twodimensional electrophoresis (2-DE) analysis revealed numerous protein variations in the EoL-1 and EoL-1-IR sub-types. Compared to the EoL-1 cells, expression levels of TIP49, RBBP7, α-enolase, adenosine deaminase, C protein, galactokinase, eukaryotic translation initiation factor, IFN-γ, and human protein homologous to DROER were increased, whereas core I protein, proteasome subunit p42, heterogeneous ribonuclear particle protein, chain B, and nucleoside diphosphate were decreased in the EoL-1-IR cells. Taken together, these results contribute to understanding the pathogenic mechanism of drug-resistant diseases.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
[학술지(정기간행물)] - Antoniu SA / 2010 / Novel therapies for hypereosinophilic syndromes / Neth J Med 68 : 304 ~ 310
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - Klion AD / 2015 / How I treat hypereosinophilic syndromes / Blood 126 : 1069 ~ 1077
[학술지(정기간행물)] - Metzgeroth G / 2008 / Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study / Br J Haematol 143 : 707 ~ 715
[학술지(정기간행물)] - Nishioka C / 2010 / Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene / Leukemia 24 : 1631 ~ 1640
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - Klion AD / 2015 / How I treat hypereosinophilic syndromes / Blood 126 : 1069 ~ 1077
[학술지(정기간행물)] - Metzgeroth G / 2008 / Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study / Br J Haematol 143 : 707 ~ 715
[학술지(정기간행물)] - Nishioka C / 2010 / Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene / Leukemia 24 : 1631 ~ 1640
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pro-apoptotic Effects of S100A8 and S100A9 on human FIP1L1-PDGFRα+ Eosinophilic Leukemia Cells
대한의생명과학회지
2021 .06
-
임종돌봄에 대한 교육의 필요성: 2개 대학병원의 인턴을 대상으로 예비 분석
한국호스피스·완화의료학회지
2017 .01
-
중환자실 간호사의 죽음에 대한 인식, 임종간호 스트레스 및임종간호 태도에 관한 연구
임상간호연구
2018 .01
-
The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1
대한의생명과학회지
2017 .03
-
Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells
Immune Network
2015 .12
-
End-of-Life Care for End-stage Heart Failure Patients
Korean Circulation Journal
2022 .09
-
Attitudes and Opinions of Elderly Patients and Family Caregivers on End-of-Life Care Discussion
Annals of geriatric medicine and research
2017 .01
-
Experiences and Opinions Related to End-of-Life Discussion: From Oncologists' and Resident Physicians' Perspectives
Cancer Research and Treatment
2018 .01
-
Treatment and Survival in Patients with Chronic Myeloid Leukemia in a Chronic Phase in West Iran
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Changes of End of Life Practices for Cancer Patients and Their Association with Hospice Palliative Care Referral over 2009-2014: A Single Institution Study
Cancer Research and Treatment
2020 .01
-
Cancer Treatment near the End-of-Life Becomes More Aggressive: Changes in Trend during 10 Years at a Single Institute
Cancer Research and Treatment
2015 .01
-
Use of generic imatinib as first-line treatment in patients with chronic myeloid leukemia (CML): the GIMS (Glivec to Imatinib Switch) study
Blood Research
2020 .01
-
노인환자와 가족의 임종의료결정 권리 및 사회복지사 역할 이해도 - 장기요양 입소 시설 사회복지사를 대상으로 -
한국호스피스·완화의료학회지
2015 .01
-
Adopting Advance Directives Reinforces Patient Participation in End-of-Life Care Discussion
Cancer Research and Treatment
2016 .01
-
간호학부 말기환자간호 교육 현황
한국호스피스·완화의료학회지
2019 .01
-
Oral and Cutaneous Lichenoid Eruption with Nail Changes Due to Imatinib Treatment in a Chinese Patient with Chronic Myeloid Leukemia
Annals of Dermatology
2015 .01
-
Therapy-related acute myeloid leukemia in a patient with B-cell acute lymphoblastic leukemia
Blood Research
2021 .12
-
First Case of Transformation of Immunoglobulin Heavy Chain Variable-Mutated Chronic Lymphocytic Leukemia Into Chronic Myeloid Leukemia
Annals of Laboratory Medicine
2019 .01
-
Chronic Myeloid Leukemia - Prognostic Value of Mutations
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
Cancer Research and Treatment
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-510-000302712