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자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제47권 제4호
발행연도
2015.1
수록면
555 - 563 (9page)

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Purpose The purpose of this study was to investigate and compare cancer treatment near theend-of-life (EOL) over a 10-year period. Materials and MethodsPatients with advanced solid cancer at Seoul National University Hospital who receivedpalliative chemotherapy and had died were enrolled. We categorized the consecutivepatients according to two time periods: 2002 (n=57) and 2012 (n=206). Aggressivenessof cancer treatment near the EOL was evaluated. ResultsThe median patient age was 62, and 65.4% of patients (n=172) were male. Time from thelast chemotherapy to death (TCD) was found to have been significantly shortened, from66.0 days to 34.0 days during 10 years (p < 0.001); 17% of patients received moleculartargeted agents as the last chemotherapy regimen in 2012. The proportion of patients whoreceived intensive care unit care within the last month increased from 1.8% in 2002 to19.9% in 2012 (p < 0.001), and emergency room visits within the last month also increasedfrom 22.8% to 74.8% (p < 0.001). Although hospice referral increased from 9.1% to 37.4%(p < 0.001), timing of referral was delayed from median 53 days to 8 days before death(p=0.004). Use of targeted agents as the last chemotherapy for over-two-regimen userswas associated with shortened TCD (hazard ratio, 2.564; p=0.002). ConclusionCancer treatment near the EOL became more aggressive over 10 years.

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