지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 313 - 318 (8page)
이용수
초록· 키워드
오류제보하기
Purification of enough numbers of circulating eosinophils is difficult because eosinophils account for less than 5% peripheral blood leukocytes. Human eosinophilic leukemia EoL-1 cells have been considered an in vitro source of eosinophils as they can differentiate into mature eosinophillike cells when incubated with dibutyryl cAMP (dbcAMP) or butyric acid. In this study, the viability and phenotypic maturation of EoL-1 cells stimulated by either dbcAMP or butyric acid were comparatively analyzed. After treatment with 100 μM dbcAMP or 0.5 μM butyric acid, EoL-1 cells showed morphological signs of differentiation, although the number of nonviable EoL-1 cells was significantly increased following butyric acid treatment. Stimulation of EoL-1 cells with 0.5 μM butyric acid more effectively induced the expression of mature eosinophil markers than stimulation with dbcAMP. These results suggest that treatment of EoL-1 cells with 0.5 μM butyric acid for limited duration could be an effective strategy for inducing their differentiation. Considering that expression of CCR3 was not sufficient in EoL-1 cells stimulated with 0.5 μM butyric acid, treatment of the chemically stimulated EoL-1 cells with cytokines, which primarily support eosinophil maturation, would help to obtain differentiated EoL-1 cells with greater functional maturity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Rothenberg, M. E. / 2006 / The eosinophil / Annu. Rev. Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Rothenberg, M. E. / 2004 / Eosinophilic gastrointestinal disorders (EGID) / J. Allergy Clin. Immunol 113 : 11 ~ 28
[학술지(정기간행물)] - Milanovic, M. / 2008 / IFN consensus sequence binding protein (Icsbp)is critical for eosinophil development / J. Immunol 181 : 5045 ~ 5053
[학술지(정기간행물)] - Hogan, S. P. / 2013 / Eosinophils in infection intestinal immunity / Curr. Opin. Gastroenterol 29 : 7 ~ 14
[학술지(정기간행물)] - Jung, Y. / 2014 / Roles regulation of gastrointestinal eosinophils in immunity disease / J. Immunol 193 : 999 ~ 1005
[학술지(정기간행물)] - Rothenberg, M. E. / 2004 / Eosinophilic gastrointestinal disorders (EGID) / J. Allergy Clin. Immunol 113 : 11 ~ 28
[학술지(정기간행물)] - Milanovic, M. / 2008 / IFN consensus sequence binding protein (Icsbp)is critical for eosinophil development / J. Immunol 181 : 5045 ~ 5053
[학술지(정기간행물)] - Hogan, S. P. / 2013 / Eosinophils in infection intestinal immunity / Curr. Opin. Gastroenterol 29 : 7 ~ 14
[학술지(정기간행물)] - Jung, Y. / 2014 / Roles regulation of gastrointestinal eosinophils in immunity disease / J. Immunol 193 : 999 ~ 1005
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UCI(KEPA) : I410-ECN-0101-2016-511-002258992