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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 221 - 229 (9page)
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초록· 키워드
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Trichophyton rubrum is one of the well-known pathogenic fungi and causes dermatophytosis and cutaneous mycosis in human world widely. However, there are not an available sequence type (ST) classification methods and previous studies for T. rubrum until now. Therefore, currently, molecular biological tools using their DNA sequences are used for genotype identification and classification. In the present study, in order to characterize the genetic diversity and the phylogenetic relation of T. rubrum clinical isolates, five different housekeeping genes, such as actin (ACT), calmodulin (CAL), RNA polymerase II (RPB2), superoxide dismutase 2 (SOD2), and β-tubulin (BT2) were analyzed using by multilocus sequence typing (MLST). Also, DNA sequence analysis was performed to examine the differences between the sequences of Trichophyton strains and the identified genetic variations sequence. As a result, most of the sequences were shown to have highly matched rates in their housekeeping genes. However, genetic variations were found on three different positions of β-tubulin gene and were shown to have changed from C→G (1766), G→T (1876), and C→A (1886). To confirm the association with T. rubrum inheritance, a phylogenetic tree analysis was performed. It was classified as four clusters, but there was little significant correlation. Even so, MLST analysis is believed to be helpful for determining the genetic variations of T. rubrum in cases where there is more large-scale data accumulation. In conclusion, the present study demonstrated the first MLST analysis of T. rubrum in Korea and explored the possibility that MLST could be a useful tool for studying the epidemiology and evolution of T. rubrum through further studies.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Anderson MJ / 1996 / Molecular typing by random amplification of polymorphic DNA and M13 Southern hybridization of related paired isolates of Aspergillus fumigatus / Journal of Clinical Microbiology 34 : 87 ~ 93
[학술지(정기간행물)] - Anne D / 2010 / Development of a new MLST scheme for differentiation of Fusarium solani species complex (FSSC) isolates / Journal of Microbiological Methods 82 : 319 ~ 323
[학술지(정기간행물)] - Atef SS / 2008 / Single-Step PCR Using (GACA) 4 Primer: Utility for Rapid Identification of Dermatophyte Species and Strains / Journal of Clinical Microbiology 46 : 2641 ~ 2645
[학술지(정기간행물)] - Balajee SA / 2006 / Molecular studies reveal frequent misidentification of Aspergillus fumigatus by morphotyping / Eukaryotic Cell 5 : 1705 ~ 1712
[학술지(정기간행물)] - Bernhardt A / 2013 / Multi locus sequence typing of Scedosporium apiospermum and Pseudallescheria boydii isolates from cystic fibrosis patients / Journal of Cystic Fibrosis 12 : 592 ~ 598
[학술지(정기간행물)] - Anne D / 2010 / Development of a new MLST scheme for differentiation of Fusarium solani species complex (FSSC) isolates / Journal of Microbiological Methods 82 : 319 ~ 323
[학술지(정기간행물)] - Atef SS / 2008 / Single-Step PCR Using (GACA) 4 Primer: Utility for Rapid Identification of Dermatophyte Species and Strains / Journal of Clinical Microbiology 46 : 2641 ~ 2645
[학술지(정기간행물)] - Balajee SA / 2006 / Molecular studies reveal frequent misidentification of Aspergillus fumigatus by morphotyping / Eukaryotic Cell 5 : 1705 ~ 1712
[학술지(정기간행물)] - Bernhardt A / 2013 / Multi locus sequence typing of Scedosporium apiospermum and Pseudallescheria boydii isolates from cystic fibrosis patients / Journal of Cystic Fibrosis 12 : 592 ~ 598
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UCI(KEPA) : I410-ECN-0101-2018-510-003599359