The Role of Oral Contraceptive Pills on Increased Risk of Breast Cancer in Iranian Populations: A Meta-analysis

Ali Soroush; Negin Farshchian; Saeid Komasi; Neda Izadi; Nasrin Amirifard; Afshar Shahmohammadi

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자료유형: 학술저널

저자정보: Ali Soroush (Kermanshah University) Negin Farshchian (Imam Reza Hospital Kermanshah University of Medical Sciences) Saeid Komasi (Kermanshah University) Neda Izadi (HSR unit of Treatment Deputy Kermanshah University of Medical Sciences) Nasrin Amirifard (Imam Reza Hospital Kermanshah University of Medical Sciences) Afshar Shahmohammadi (Imam Ali and Taleghani Hospital Kermans)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제21권 제4호

발행연도: 2016.1

수록면: 294 - 301 (8page)

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연구방법

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Background: Cancer is one of the main public health issues in the world. Breast cancer is one of the most common types of cancer among women. It is also the second cause of mortality in women. The association between the use of oral contraceptive pills and breast cancer is controversial and a main issue in public health. Some findings have shown that taking these pills does not have a significant effect in increasing the risk of breast cancer, while others have confirmed the carcinogenic effect of these products. These contradictory findings necessitated this meta-analysis, through of all correlated studies in Iran. Methods: All published studies were considered from June 2000 until June 2015, using reliable Latin databases like PubMed, Google Scholar, Google search, Scopus, and Science Direct, and Persian database like SID, Irandoc, IranMedex, and Magiran. Finally, 26 papers were selected: 24 studies were case control while two were population based studies. A total of 26 papers with 46,260 participants were assessed since 2001. Results: Overall estimate of OR for the effect of oral contraceptive pills on breast cancer is 1.521 (CI = 1.25-1.85), which shows that the intervention group had more chance (52%) compared to the control group (P = 0.001). Using these pills increased the risk of breast cancer up to 1.52 times. Conclusions: Because of directly increasing levels of estrogen and the role of estrogen in gaining weight indirectly, oral contraceptive pills can stimulate the occurrence of breast cancer. More studies should be conducted for controlling the period of pill use.

참고문헌 (60)

참고문헌 신청

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