지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 55 - 67 (13page)
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초록· 키워드
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γδ T cells are abundant in the gut mucosa and play an important role in adaptive immunity as well as innate immunity. Although γδ T cells are supposed to be associated with the enhancement of Ab production, the status of γδ T cells, particularly in the synthesis of IgA isotype, remains unclear. We compared Ig expression in T cell receptor delta chain deficient (TCRδ<SUP>+</SUP>) mice with wild-type mice. The amount of IgA in fecal pellets was substantially elevated in TCRδ<SUP>+</SUP> mice. This was paralleled by an increase in surface IgA expression and total IgA production by Peyer"s patches (PPs) and mesenteric lymph node (MLN) cells. Likewise, the TCRδ<SUP>+</SUP> mice produced much higher levels of serum IgA isotype. Here, surface IgA expression and number of IgA secreting cells were also elevated in the culture of spleen and bone marrow (BM) B cells. Germ-line α transcript, an indicator of IgA class switch recombination, higher in PP and MLN B cells from TCRδ<SUP>+</SUP> mice, while it was not seen in inactivated B cells. Nevertheless, the frequency of IgA<SUP>+</SUP> B cells was much higher in the spleen from TCRδ<SUP>+</SUP> mice. These results suggest that γδ T cells control the early phase of B cells, in order to prevent unnecessary IgA isotype switching. Furthermore, this regulatory role of γδ T cells had lasting effects on the long-lived IgA-producing plasma cells in the BM.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Born WK / 2017 / ${\gamma}{\delta}$ T cells and B cells / Adv Immunol 134:1~45
Horner AA / 1995 / Gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes / J Exp Med 181:1239~1244
Strid J / 2011 / The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy / Science 334:1293~1297
Ehl S / 2005 / A variant of SCID with specific immune responses and predominance of gamma delta T cells / J Clin Invest 115:3140~3148
Toyabe S / 2001 / Oligoclonally expanding gammadelta T lymphocytes induce IgA switching in IgA nephropathy / Clin Exp Immunol 124:110~117
Horner AA / 1995 / Gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes / J Exp Med 181:1239~1244
Strid J / 2011 / The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy / Science 334:1293~1297
Ehl S / 2005 / A variant of SCID with specific immune responses and predominance of gamma delta T cells / J Clin Invest 115:3140~3148
Toyabe S / 2001 / Oligoclonally expanding gammadelta T lymphocytes induce IgA switching in IgA nephropathy / Clin Exp Immunol 124:110~117
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UCI(KEPA) : I410-ECN-0101-2018-517-003392100