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논문 기본 정보

자료유형
학술저널
저자정보
Ha-Yan Park (Konyang University) Sang-Hoon Lee (Konyang University) Kyu-Seon Lee (Konyang University) Hee-Kyung Yoon (Konyang University) Yung-Choon Yoo (Konyang University) Junglim Lee (Konyang University) Jae Eul Choi (Chungnam National University) Pyeung-Hyeun Kim (Kangwon National University) Seok-Rae Park (Konyang University)
저널정보
대한면역학회 Immune Network Immune Network Vol.15 No.6
발행연도
2015.12
수록면
331 - 336 (6page)

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Ginsenosides are the major components of ginseng, which is known to modulate blood pressure, metabolism, and immune function, and has been used to treat various diseases. It has been reported that ginseng and several ginsenosides have immunoregulatory effects on the innate and T cellmediated immune response. However, their effects on the humoral immune response have not been fully explored. The present study examined the direct effects of red ginseng extract (RGE) and ginsenosides on mouse B cell proliferation and on antibody production and the expression of germline transcripts (GLT) by mouse B cells in vitro. RGE slightly reduced B cell proliferation, but increased IgA production by LPS-stimulated B cells. Furthermore, ginsenoside Rg1 and 20(S)-Rg3 selectively induced IgA production and expression of GLTα transcripts by LPS-stimulated B cells. Collectively, these results suggest that ginsenoside Rg1 and 20(S)-Rg3 can drive the differentiation of B cells into IgA-producing cells through the selective induction of GLTα expression.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2016-511-002259020