지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 37 - 43 (7page)
이용수
초록· 키워드
오류제보하기
It is well established that TGF-β1 and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching in spleen B cells. The present study explored the effect of LF on the Ig production by mouse peritoneal B cells. LF, like TGF-β1, substantially increased IgA production in peritoneal B1 cells but little in peritoneal B2 cells. In contrast, LF increased IgG2b production in peritoneal B2 cells much more strongly than in peritoneal B1 cells. LF in combination with RA further enhanced the IgA production and, interestingly, this enhancement was restricted to IgA isotype and B1 cells. Similarly, the combination of the two molecules also led to expression of gut homing molecules α4β7 and CCR9 on peritoneal B1 cells, but not on peritoneal B2 cells. Thus, these results indicate that LF and RA can contribute to gut IgA response through stimulating IgA isotype switching and expression of gut-homing molecules in peritoneal B1 cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Hayakawa, K. / 1983 / The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice / J. Exp. Med 157 : 202 ~ 218
2. [학술지(정기간행물)] - Gray, D. / 1982 / Migrant mu＋ delta＋ and static mu＋ delta− B lymphocyte subsets / Eur. J. Immunol 12 : 564 ~ 569
3. [학술지(정기간행물)] - Timens, W. / 1989 / Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation / Eur. J. Immunol 19 : 2163 ~ 2166
4. [학술지(정기간행물)] - Cerutti, A. / 2013 / Marginal zone B cells:virtues of innate-like antibody-producing lymphocytes / Nat. Rev. Immunol 13 : 118 ~ 132
5. [학술지(정기간행물)] - Marcos, M. A. / 1989 / Further evidence for coelomic-associated B lymphocytes / Eur. J. Immunol 19 : 2031 ~ 2035
2. [학술지(정기간행물)] - Gray, D. / 1982 / Migrant mu＋ delta＋ and static mu＋ delta− B lymphocyte subsets / Eur. J. Immunol 12 : 564 ~ 569
3. [학술지(정기간행물)] - Timens, W. / 1989 / Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation / Eur. J. Immunol 19 : 2163 ~ 2166
4. [학술지(정기간행물)] - Cerutti, A. / 2013 / Marginal zone B cells:virtues of innate-like antibody-producing lymphocytes / Nat. Rev. Immunol 13 : 118 ~ 132
5. [학술지(정기간행물)] - Marcos, M. A. / 1989 / Further evidence for coelomic-associated B lymphocytes / Eur. J. Immunol 19 : 2031 ~ 2035
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UCI(KEPA) : I410-ECN-0101-2016-511-001754557