Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer

Marco Vella; Daniela Coniglio; Alberto Abrate; Cristina Scalici Gesolfo; Elena Lo Presti; Serena Meraviglia; Vincenzo Serretta; Alchiede Simonato

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자료유형: 학술저널

저자정보: Marco Vella (University of Palermo) Daniela Coniglio (University of Palermo) Alberto Abrate (University of Palermo) Cristina Scalici Gesolfo (University of Palermo) Elena Lo Presti (University of Palermo) Serena Meraviglia (University of Palermo) Vincenzo Serretta (University of Palermo) Alchiede Simonato (University of Palermo)

저널정보: 대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.60 No.2

발행연도: 2019.1

수록면: 91 - 98 (8page)

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Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.

#Biopsy #Immunologic surveillance #Neoplasm grading #Prostatic neoplasms #T-Lymphocyte subsets

참고문헌 (30)

참고문헌 신청

Albertsen PC / 2005 / 20-year outcomes following conservative management of clinically localized prostate cancer / JAMA 293:2095~2101

Thompson IM / 2003 / The influence of finasteride on the development of prostate cancer / N Engl J Med 349:215~224

De Marzo AM / 2007 / Inflammation in prostate carcinogenesis / Nat Rev Cancer 7:256~269

Hao J / 2010 / Current progress in γδ T-cell biology / Cell Mol Immunol 7:409~413

Dieli F / 2003 / Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo / Blood 102:2310~2311

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