지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: This systematic review and meta-analysis provided scientific evidence for oral cryotherapy as a nursing intervention for the prevention of Oral Mucositis (OM) associated with Hematopoietic Stem Cell Transplantation (HSCT). Methods: The literature search was carried out in July and October 2017. The MEDLINE, EMBASE, Cochrane Library, CINAHL, and KoreaMed electronic databases were searched using the MeSH keywords “mucositis” and “cryotherapy.” The Cochrane’s Risk of Bias tool was used to assess the internal validity of the Randomized Controlled Trials (RCTs). The selected studies were included in the meta-analysis using Review Manager 5.3. Results: Among seven RCTs with 264 patients, oral cryotherapy significantly decreased the incidence of OM (Relative Risk [RR]=0.46, 95% Confidence Interval [CI]=0.31~0.66), including severe OM (grade 2~4: RR=0.33, 95% CI=0.21~0.52; grade 3~4: RR=0.34, 95% CI, 0.22~0.53), and also reduced the OM severity score (Standardized Mean Difference [SMD]=-0.92, 95% CI=-1.25~-0.58). In addition, the need of intravenous narcotics therapy (RR=0.19, 95% CI=0.07~0.51) and the total parenteral nutrition (RR=0.54, 95% CI=0.35~0.84) were reduced. These results were associated with a significantly reduced length of hospitalization (Weighted Mean Difference [WMD]=-1.22, 95% CI=-2.37~-0.07). Conclusion: Oral cryotherapy is effective and well-tolerated nursing intervention to alleviate OM among patients receiving myeloablative therapy before HSCT. Nurses caring for patients treated with myeloablative therapy should place high priority to prevent OM based on this evidence.
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UCI(KEPA) : I410-ECN-0101-2018-512-003334489