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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 371 - 377 (7page)
이용수
초록· 키워드
오류제보하기
Otitis media (OM) is one of the most common inflammatory illnesses in the pediatric population. OM is a multifactorial disease that develops as a result of complex interactions between bacterial infection, environmental risk factors, and host genetic factors. The high prevalence and recurrence of OM, coupled with the risk of developing hearing loss have meant that research to understand the mechanisms of OM and identify new therapeutic measures is urgent. Various experimental animals such as chinchilla, guinea pig, gerbil, rat and mouse have been used to investigate the pathogenesis and treatment of OM. Also, a lot of methods have been introduced to induce OM in animals including obstruction of E tube and direct injection of otopathogens into the middle ear. Recently there has been an increase in the use of the mouse for OM research due to the ability to easily manipulate their genetic components. The use of animal models has enabled researchers to identify a number of molecular mechanisms involved in the development of OM. Despite the real progresses obtained from animal models of OM, however, there are still several limitations to using them for OM research. In this review article, various animal models that have been introduced to investigate the pathogenesis of OM will be discussed briefly.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bakaletz LO / 2009 / Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention / Expert Rev Vaccines 8 (8) : 1063 ~ 1082
Bedell MA / 1997 / Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice / Genes Dev 11 (1) : 1 ~ 10
Bedell MA / 1997 / Mouse models of human disease. Part II: recent progress and future directions / Genes Dev 11 (1) : 11 ~ 43
Brown SD / 2001 / Systematic approaches to mouse mutagenesis / Curr Opin Genet Dev 11 (3) : 268 ~ 273
Costantini F / 1981 / Introduction of a rabbit beta-globin gene into the mouse germ line / Nature 294 (5836) : 92 ~ 94
Bedell MA / 1997 / Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice / Genes Dev 11 (1) : 1 ~ 10
Bedell MA / 1997 / Mouse models of human disease. Part II: recent progress and future directions / Genes Dev 11 (1) : 11 ~ 43
Brown SD / 2001 / Systematic approaches to mouse mutagenesis / Curr Opin Genet Dev 11 (3) : 268 ~ 273
Costantini F / 1981 / Introduction of a rabbit beta-globin gene into the mouse germ line / Nature 294 (5836) : 92 ~ 94
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