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Effects of Dietary Supplementation with Allium hookeri Root on the Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats
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삼채 뿌리 보충식이가 당뇨 흰쥐의 조직에서 항산화효소 활성도에 미치는 영향

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Type
Academic journal
Author
Myung-Wha Kim (덕성여자대학교) Hye Kyoung Han (덕성여자대학교)
Journal
The East Asian Society Of Dietary Life Journal of the East Asian Society of Dietary Life Vol.28 No.3 KCI Accredited Journals
Published
2018.6
Pages
179 - 187 (9page)
DOI
10.17495/easdl.2018.6.28.3.179

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Effects of Dietary Supplementation with Allium hookeri Root on the Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats
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This study examined the effects of Allium hookeri (AH) root on the antioxidant defense in streptozotocin (STZ)-induced diabetic rats. Rats were rendered diabetic by STZ (45 mg/kg body weight) administration. The experimental groups were divided into four groups: a normal-control (N-control), STZ-control, STZ-AH 5%, and STZ-AH 10% supplemented groups. The N-control and STZ-control group were fed an AIN-93 diet, and the experimental groups were fed a modified diet containing 5% and 10% of AH root powder for 4 weeks. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and xanthine oxidase (XOD) were measured in the kidney, lung, and brain. The SOD activities in the lung and brain were significantly lower in the STZ-AH 10% group than in the STZ-control group. The activity of CAT in the kidney was significantly higher in the STZ-AH 10% group than in the STZ-control group. The GR activities in the kidney and lung were reduced in STZ-AH 5% and STZ-AH 10% group, respectively. In the kidney, the activity of GPx was significantly higher in the STZ-AH 5% group than in the STZ-control group. Similar results were observed for the lung. The GST activity was significantly lower in the STZ-AH 5% group in the kidney but significantly higher in the STZ-AH 10% group in the lung compared to the STZ-control group. The XOD activities in the kidney and brain were significantly lower in the STZ-AH 10% group than in the STZ-control group. Allium hookeri root contains bioactive compounds that possess important antioxidant properties and protected the kidneys, lung and brain from hyperglycemia damage.

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UCI(KEPA) : I410-ECN-0101-2018-594-003167322