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Alleviating Effects of Mulberry Fruit Extract on Postprandial Hyperglycemia in Streptozotocin-induced Diabetic Mice
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Type
Academic journal
Author
Kyung Ha Choi (Pusan National University) Ji-Hye Kang (Pusan National University) Ji-Sook Han (Pusan National University)
Journal
Korean Society Of Life Science Journal of Life Science Vol.26 No.8 KCI Accredited Journals
Published
2016.8
Pages
921 - 927 (7page)

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Alleviating Effects of Mulberry Fruit Extract on Postprandial Hyperglycemia in Streptozotocin-induced Diabetic Mice
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Postprandial hyperglycemia is an early defect of type 2 diabetes and one of primary anti-diabetic targets. The alpha-glucosidase inhibitors regulate postprandial hyperglycemia by impeding the rate of carbohydrate (such as starch) digestion in the small intestine. This study was designed to investigate the inhibitory actions of mulberry fruit extract (MFE) on α-glucosidase and α-amylase activities, and its alleviating effect on postprandial hyperglycemia activities in vitro and in vivo. Male four-week old ICR mice and streptozotocin (STZ)-induced diabetic mice were treated with mulberry fruit extract. MFE showed strong inhibitory effects against α-glucosidase and α-amylase activities, with half-maximal inhibitory concentration (IC50) values of 0.16 and 0.14 mg/ml, respectively, and was more effective than acarbose, which was used as a positive control. The increase in postprandial blood glucose levels was more significantly attenuated in the MFE-administered group mice than in the control group mice of both STZ-induced diabetic and normal mice. Moreover, the area under the glucose response curve significantly decreased following MFE administration in diabetic mice. These results indicate that MFE may be a potent inhibitor of α-glucosidase and α-amylase, and helpful in suppressing postprandial hyperglycemia in diabetic mice. The mulberry fruit extracts may be considered as a potential candidate for the management of diabetes.
#α-Amylase #α-Glucosidase #diabetic mice #mulberry fruit extract #postprandial hyperglycemia

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Materials and Methods
Results and Discussion
References
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References (36)

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[학술지(정기간행물)] - Abrahamson, M. J / 2004 / Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context / Arch. Intern. Med 164 : 486 ~ 491 google schola [학술지(정기간행물)] - Baron A. D / 1998 / Postprandial hyperglycemia and α-glucosidase inhibitors / Diabetes Res. Clin. Pract 40 : 51 ~ 55 google schola [학술지(정기간행물)] - Bhandari, M. R. / 2007 / α-glucosidase and α-amylase inhibitory activities of nepalese medicinal herb pakhanbhed (Bergenia ciliata, Haw.) / Food Chem 106 : 247 ~ 252 google schola [학술지(정기간행물)] - 최수정 / 2015 / Isolation and Development of Quantification Method for Cyanidin-3-Glucoside and Cyanidin-3-Rutinoside in Mulberry Fruit by High-Performance Countercurrent Chromatography and High-Performance Liquid Chromatography / Natural Product Sciences 21 (1) : 20 ~ 24 google schola [학술지(정기간행물)] - Hanefeld, M / 1998 / The role of acarbose in the treatment of non-insulin-dependent diabetes mellitus / J. Diabetes Complications 12 : 228 ~ 237 google schola

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