지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 389 - 399 (11page)
이용수
초록· 키워드
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Background: The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-EE) exerts skin-protective effects, we studied its activities in activated melanocytes and reactive oxygen species (ROS)einduced keratinocytes.
Methods: To confirm the antimelanogenesis effect of Pg-C-EE, we analyzed melanin synthesis and secretion and messenger RNA and protein expression levels of related genes. Ultraviolet B (UVB) and hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) were used to induce cell damage by ROS generation. To examine whether this damage is inhibited by Pg-C-EE, we performed cell viability assays and gene expression and transcriptional activation analyses.
Results: Pg-C-EE inhibited melanin synthesis and secretion by blocking activator protein 1 regulatory enzymes such as p38, extracellular signal-regulated kinases (ERKs), and cyclic adenosine monophosphate response elementebinding protein. Pg-C-EE also suppressed ROS generation induced by H<SUB>2</SUB>O<SUB>2</SUB> and UVB. Treatment with Pg-C-EE decreased the expression of matrix metalloproteinases, mitogenactivated protein kinases, and hyaluronidases and increased the cell survival rate.
Conclusion: These results suggest that Pg-C-EE may have antimelanogenesis properties and skin-protective properties through regulation of activator protein 1 and cyclic adenosine monophosphate response elementebinding protein signaling. Pg-C-EE may be used as a skin-improving agent, with moisture retention and whitening effects.
Methods: To confirm the antimelanogenesis effect of Pg-C-EE, we analyzed melanin synthesis and secretion and messenger RNA and protein expression levels of related genes. Ultraviolet B (UVB) and hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) were used to induce cell damage by ROS generation. To examine whether this damage is inhibited by Pg-C-EE, we performed cell viability assays and gene expression and transcriptional activation analyses.
Results: Pg-C-EE inhibited melanin synthesis and secretion by blocking activator protein 1 regulatory enzymes such as p38, extracellular signal-regulated kinases (ERKs), and cyclic adenosine monophosphate response elementebinding protein. Pg-C-EE also suppressed ROS generation induced by H<SUB>2</SUB>O<SUB>2</SUB> and UVB. Treatment with Pg-C-EE decreased the expression of matrix metalloproteinases, mitogenactivated protein kinases, and hyaluronidases and increased the cell survival rate.
Conclusion: These results suggest that Pg-C-EE may have antimelanogenesis properties and skin-protective properties through regulation of activator protein 1 and cyclic adenosine monophosphate response elementebinding protein signaling. Pg-C-EE may be used as a skin-improving agent, with moisture retention and whitening effects.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (48)
참고문헌 신청
[학술지(정기간행물)] - Murphy K / 2016 / Janeway's immunobiology / Garland Science
[단행본] - Wilkinson P / 1983 / Skin (Digitally printed version ed.) / Cambridge university press
[학술지(정기간행물)] - Kumar CM / 2011 / Interaction of sesamol (3, 4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis / Biochimie 93 : 562 ~ 569
[학술지(정기간행물)] - Laskin JD / 1982 / Control of melanin synthesis and secretion by B16/C3 melanoma cells / J Cell Physiol 113 : 481 ~ 486
[학술지(정기간행물)] - Kim SS / 2013 / Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma / Asian Pac J Trop Biomed 3 : 617 ~ 622
[단행본] - Wilkinson P / 1983 / Skin (Digitally printed version ed.) / Cambridge university press
[학술지(정기간행물)] - Kumar CM / 2011 / Interaction of sesamol (3, 4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis / Biochimie 93 : 562 ~ 569
[학술지(정기간행물)] - Laskin JD / 1982 / Control of melanin synthesis and secretion by B16/C3 melanoma cells / J Cell Physiol 113 : 481 ~ 486
[학술지(정기간행물)] - Kim SS / 2013 / Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma / Asian Pac J Trop Biomed 3 : 617 ~ 622
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UCI(KEPA) : I410-ECN-0101-2018-524-003161286