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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 134 - 137 (4page)
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초록· 키워드
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S100A8 and S100A9 are involved in pathogenesis of cancer by induction or inhibition of cancer as well as inflammation. In this study, we investigated the association of S100A8 and S100A9 with pathogenesis of leukemia using human monocytic leukemia cells, THP-1. The expression of TLR4, which is a known receptor of S100A8 and S100A9, was examined by using flow cytometry and Western blotting. THP-1 cells have high surface and cytosol expression of TLR4. S100A8 and S100A9 suppressed the cell survival, and this suppression was found to be associated with apoptosis because they increased the number of apoptotic cells in a dose- and a time-dependent manners. However, S100A8 and S100A9 had no effect on the survival and apoptosis of monocytes isolated from the peripheral blood. We next examined the apoptotic effect of lipopolysaccharide (LPS) and monophosphoryl lipid A (MPLA), which are other ligands of TLR4, in THP-1 cells. Lipopolysaccharide had no effect on cell survival, but MPLA is effective on the cell apoptosis. These results suggest that S100A8 and S100A9 may regulate leukemia cell survival via TLR4, which is an essential receptor in the pro-apoptotic mechanism induced by S100A8 and S100A9. These findings may shed light on development of a possible therapeutic drug for leukemia treatment.
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REFERENCES
참고문헌 (14)
참고문헌 신청
[학술지(정기간행물)] - Austermann J / 2017 / S100-alarmins: potential therapeutic targets for arthritis / Expert Opin Ther Targets 21 : 739 ~ 751
[학술지(정기간행물)] - Goyette J / 2011 / Inflammation-associated S100 proteins: new mechanisms that regulate function / Amino Acids 41 : 821 ~ 842
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - 김인식 / 2017 / S100A8 and S100A9 Secreted by Allergens in Monocytes Inhibit Spontaneous Apoptosis of Normal and Asthmatic Neutrophils via the Lyn/Akt/ERK Pathway / 대한임상검사과학회지 49 (2) : 128 ~ 134
[학술지(정기간행물)] - Laouedj M / 2017 / S100A9 induces differentiation of acute myeloid leukemia cells through TLR4 / Blood 129 : 1980 ~ 1990
[학술지(정기간행물)] - Goyette J / 2011 / Inflammation-associated S100 proteins: new mechanisms that regulate function / Amino Acids 41 : 821 ~ 842
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - 김인식 / 2017 / S100A8 and S100A9 Secreted by Allergens in Monocytes Inhibit Spontaneous Apoptosis of Normal and Asthmatic Neutrophils via the Lyn/Akt/ERK Pathway / 대한임상검사과학회지 49 (2) : 128 ~ 134
[학술지(정기간행물)] - Laouedj M / 2017 / S100A9 induces differentiation of acute myeloid leukemia cells through TLR4 / Blood 129 : 1980 ~ 1990
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