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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 197 - 203 (7page)
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Decursin is a major component of the root of Angelica gigas(Umbelliferae), which has been traditionally used in Korea as a tonic and to treat anemia, hemiplegia, and women’s diseases. The objective of this study is to identify the anti-cancer mechanism induced by decursin on apoptosis of human leukemia and lymphoma cells. Cytotoxicity of decursin on U937, HL- 60, MOLT-4, THP-1 cells showed the significant effects. First of all, IC<SUB>50</SUB> of decursin on four cell lines was 27.1, 32.4, 17.4, 15.1 μM, respectively. So IC<SUB>50</SUB> in THP-1 cells was the smallest among 4 cell lines treated with decursin(15.1 μM). In order to understand the apoptosis-mechanism by decursin, we examined the gene expression of bcl- (anti-apoptotic), bax(pro-apoptotic) and p53(tumor suppressor)after treating the THP-1 cells with decursin(10, 50 and 100 μM). It was found bcl-2 gene was decreased dose dependently, the expression level of bax gene of THP-1 cells treated with 100 μM of decursin was about 3 times higher than those of control, and p53 gene was increased In the same concentration(100 μM), p53 gene was increased dose dependent manner. In protein express, bcl-2 and p53 protein showed a tendency to decrease. bax was increased about 4 fold. Therefore decursin is a useful chemotherapeutic agent against leukemia.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
국립암센터 / 2014 / Annual report of cancer statistics in Korea in 2012 :1~179
조영자 / 2005 / 뽕잎, 감초, 솔잎 및 당귀분말이 흰쥐의 혈청조성에 미치는 영향 / 한국식생활문화학회지 20(1):123~129
Han, E. J. / 2000 / Effects of quinone reductase induction and cytoxicity of the Angelica radix extracts / J. Korean Soc. Food Sci. Nutr. 29:147~152
이현용 / 2005 / 초음파 병행 추출을 이용한 마황과 복분자, 당귀 분획물의 면역활성 조절 효과 / 한국약용작물학회지 13(4):161~170
Wessler, S. / 1974 / Coumarin theraphy in acute myocardial infarction. A hobson’s choice / Arch. Intem. Med. 134:774~779
조영자 / 2005 / 뽕잎, 감초, 솔잎 및 당귀분말이 흰쥐의 혈청조성에 미치는 영향 / 한국식생활문화학회지 20(1):123~129
Han, E. J. / 2000 / Effects of quinone reductase induction and cytoxicity of the Angelica radix extracts / J. Korean Soc. Food Sci. Nutr. 29:147~152
이현용 / 2005 / 초음파 병행 추출을 이용한 마황과 복분자, 당귀 분획물의 면역활성 조절 효과 / 한국약용작물학회지 13(4):161~170
Wessler, S. / 1974 / Coumarin theraphy in acute myocardial infarction. A hobson’s choice / Arch. Intem. Med. 134:774~779
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