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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 104 - 109 (6page)
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The purpose of this study was to evaluate the inhibitory effect of commercial Makgeolli on tumor growth in human gastric adenocarcinoma cells (AGS) in a xenograft cancer model, transplanted with AGS cells. Commercial Makgeolli was first dealcoholized by evaporation and used as the test sample. We detected a significant increase in the volume and weight of tumor in nude mice (induction) that were transplanted with AGS cells. Administration of 100 mg/kg·day group (ML), and 500 mg/kg·day group (MH) dealcoholized commercial Makgeolli significantly decreased tumor growth. In this study, 5-FU 18 mg/kg·day was used as a positive control for tumor growth inhibition. Additionally, determination of the body weight of both the groups revealed no side effects after the administration of dealcoholized commercial Makgeolli. Using the cell culture system, we also evaluated the effect of dealcoholized commercial Makgeolli on caspase-3/7 activity in the AGS cells. Treatment with dealcoholized commercial Makgeolli increased the activation of caspase-3/7 and the apoptotic markers in AGS cells in a dose-dependent manner. Therefore, dealcoholized commercial Makgeolli can be used for cancer prevention.
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참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Zhong C / 2012 / Sodium intake, salt taste and gastric cancer risk according to Helicobacter pylori infection, smoking, histological type and tumor site in China / Asian Pac J Cancer Prev 13 : 2481 ~ 2484
[학술지(정기간행물)] - Cazzaniga M / 2012 / Breast cancer chemoprevention: old and new approaches / J Biomed Biotechnol 2012 : 1 ~ 15
[학술지(정기간행물)] - Hu G / 2014 / Downstream carcinogenesis signaling pathways by green tea polyphenols: a translational perspective of chemoprevention and treatment for cancers / Curr Drug Metab 15 : 14 ~ 22
[학술지(정기간행물)] - Park EJ / 2013 / Antioxidant marine products in cancer chemoprevention / Antioxid Redox Signal 19 : 115 ~ 138
[학술지(정기간행물)] - Lin HY / 2011 / Resveratrol and apoptosis / Ann N Y Acad Sci 1215 : 79 ~ 88
[학술지(정기간행물)] - Cazzaniga M / 2012 / Breast cancer chemoprevention: old and new approaches / J Biomed Biotechnol 2012 : 1 ~ 15
[학술지(정기간행물)] - Hu G / 2014 / Downstream carcinogenesis signaling pathways by green tea polyphenols: a translational perspective of chemoprevention and treatment for cancers / Curr Drug Metab 15 : 14 ~ 22
[학술지(정기간행물)] - Park EJ / 2013 / Antioxidant marine products in cancer chemoprevention / Antioxid Redox Signal 19 : 115 ~ 138
[학술지(정기간행물)] - Lin HY / 2011 / Resveratrol and apoptosis / Ann N Y Acad Sci 1215 : 79 ~ 88
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UCI(KEPA) : I410-ECN-0101-2018-059-003060419