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Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells
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논문 기본 정보

Type
Academic journal
Author
Myoung-Sik Han (University of Ulsan College of Medicine) Im-Ho Han (Gangneung-Wonju National University) Dahae Lee (Gachon University) Jun Min An (GINSENG BY PHARM) Su-Nam Kim (Korea Institute of Science and Technology) Myoung-Sook Shin (Korea Institute of Science and Technology) Noriko Yamabe (Gachon University)
Journal
The Korean Society of Ginseng Journal of Ginseng Research Vol.40 No.2 KCI Candidated Journals SCIE
Published
2016.4
Pages
135 - 140 (6page)

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Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells
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Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the bestknown herbal medicines, and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity, as well as the specific constituents mediating this effect, have recently emerged as an interesting research area focusing on the kidney protective efficacy of P. ginseng.
Methods: The present study investigated the kidney protective effect of fermented black ginseng (FBG) and its active component ginsenoside 20(S)-Rg3 against cisplatin (chemotherapy drug)-induced damage in pig kidney (LLC-PK1) cells. It focused on assessing the role of mitogen-activated protein kinases as important mechanistic elements in kidney protection.
Results: The reduced cell viability induced by cisplatin was significantly recovered with FBG extract and ginsenoside 20(S)-Rg3 dose-dependently. The cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), p53, and cleaved caspase-3 were decreased after cotreatment with FBG extract or ginsenoside 20(S)-Rg3. The elevated percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment was significantly abrogated by cotreatment with FBG and the ginsenoside 20(S)-Rg3.
Conclusion: FBG and its major ginsenoside 20(S)-Rg3, ameliorated cisplatin-induced nephrotoxicity in LLC-PK1 cells by blocking the JNK-p53-caspase-3 signaling cascade.
#cisplatin #ginsenoside 20(S)-Rg3 #mitogen-activated protein kinases #nephrotoxicity #Panax ginseng

Contents

ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References

References (32)

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[학술지(정기간행물)] - Lee YK / 2013 / Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats / Food Chem Toxicol 59 : 153 ~ 159 google schola [학술지(정기간행물)] - El-Khayat Z / 2011 / Protective effect of Panax ginseng against streptozotocin induced renal dysfunction in rats / J Appl Sci Res 7 : 1419 ~ 1423 google schola [학술지(정기간행물)] - Quan Hai Yan / 2013 / Korean red ginseng extract alleviates advanced glycation end productmediated renal injury / Journal of Ginseng Research 37 (2) : 187 ~ 193 dbpia [학술지(정기간행물)] - Nasiri-Toosi Z / 2013 / A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity / Eur J Clin Pharmacol 69 : 1057 ~ 1073 google schola [학술지(정기간행물)] - Choudhury D / 2006 / Drug-associated renal dysfunction and injury / Nat Clin Pract Nephrol 2 : 80 ~ 91 google schola

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