지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 187 - 193 (7page)
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초록· 키워드
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The effect of Korean red ginseng (KRG) on diabetic renal damage was investigated using streptozotocin (STZ)-induced diabetic rats. The diabetic rats showed loss of body weight gain, and increases in kidney weight and urine volume, whereas the oral administration of KRG at a dose of 100 or 250 mg/kg of body weight per day for 28 d prevented these diabetes-induced physiological abnormalities. Among the kidney function parameters, elevated plasma levels of urea nitrogen and creatinine in diabetic control rats tended to be lowered in KRG-treated rats. In addition, administration of KRG at a dose of 100 mg/kg body weight in the diabetic rats showed significant decreases in serum glucose and tumor necrosis factor-a (TNF-a), implying that KRG might prevent the pathogenesis of diabetic complications caused by impaired glucose metabolism and oxidative stress. KRG also significantly reduced advanced glycation end product (AGE) formation and secretion from kidney of diabetic rats. Furthermore, KRG decreased the levels of N-(carboxymethyl) lysine and expression of AGE receptor. KRG also reduced the overexpression of cyclooxygenase-2 and inducible nitric oxide synthase in the kidney via deactivation of nuclear factor-kappa B. We also found that KRG prevented STZ-induced destruction of glomerular structure and significantly suppressed high glucose-induced fibronectin production. Taken together, KRG ameliorates abnormalities associated with diabetic nephropathy through suppression of inflammatory pathways activated by TNF-a and AGEs. These findings indicate that KRG has a beneficial effect on pathological conditions associated with diabetic nephropathy.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Karihaloo A. / 2012 / Anti-fibrosis therapy and diabetic nephropathy / Curr Diab Rep 12 : 414 ~ 422
2. [학술지(정기간행물)] - Zhou X / 2012 / A novel improved therapy strategy for diabetic nephropathy: targeting AGEs / Organogenesis 8 : 18 ~ 21
3. [학술지(정기간행물)] - Yang CY / 2010 / Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components / J Ethnopharmacol 130 : 231 ~ 236
4. [학술지(정기간행물)] - Yuan HD / 2011 / Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways / Metabolism 60 : 43 ~ 51
5. [학술지(정기간행물)] - Lee HJ / 2009 / Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats / Metabolism 58 : 1170 ~ 1177
2. [학술지(정기간행물)] - Zhou X / 2012 / A novel improved therapy strategy for diabetic nephropathy: targeting AGEs / Organogenesis 8 : 18 ~ 21
3. [학술지(정기간행물)] - Yang CY / 2010 / Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components / J Ethnopharmacol 130 : 231 ~ 236
4. [학술지(정기간행물)] - Yuan HD / 2011 / Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways / Metabolism 60 : 43 ~ 51
5. [학술지(정기간행물)] - Lee HJ / 2009 / Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats / Metabolism 58 : 1170 ~ 1177
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UCI(KEPA) : I410-ECN-0101-2014-520-003018733