지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 595 - 601 (7page)
이용수
초록· 키워드
오류제보하기
Background: Red ginseng oil (RGO) is produced by supercritical CO₂ extraction of secondary products derived from Korean Red Ginseng extract. As the use of RGO has increased, product safety concerns have become more important.
Methods: In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of RGO were evaluated. SpragueeDawley rats were orally administered with RGO for 28 d by gavage. Daily RGO dose concentrations were 0 mg/kg body weight (bw), 500 mg/kg bw, 1,000 mg/kg bw, or 2,000 mg/kg bw per day. Bacterial reverse mutation tests included five bacterial strains (Escherichia coli WP2 and Salmonella typhimurium TA98, TA100, TA1535, and TA1537), which were used in the presence or absence of metabolic activation. The plated incorporation method for mutation test was used with RGO concentrations ranging from 312.5 mg to 5,000 mg per plate.
Results: The subacute oral toxicity test results did not reveal any marked changes in clinical characteristics. There were no toxicological changes related to RGO administration in hematological and serum biochemical characteristics in either control or treatment animals. Furthermore, no gross or histopathological changes related to RGO treatment were observed. The bacterial reverse mutation test results did not reveal, at any RGO concentration level and in all bacterial strains, any increase in the number of revertant colonies in the RGO treatment group compared to that in the negative control group.
Conclusion: The no-observed-adverse-effect level of RGO is greater than 2,000 mg/kg bw and RGO did not induce genotoxicity related to bacterial reverse mutations.
Methods: In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of RGO were evaluated. SpragueeDawley rats were orally administered with RGO for 28 d by gavage. Daily RGO dose concentrations were 0 mg/kg body weight (bw), 500 mg/kg bw, 1,000 mg/kg bw, or 2,000 mg/kg bw per day. Bacterial reverse mutation tests included five bacterial strains (Escherichia coli WP2 and Salmonella typhimurium TA98, TA100, TA1535, and TA1537), which were used in the presence or absence of metabolic activation. The plated incorporation method for mutation test was used with RGO concentrations ranging from 312.5 mg to 5,000 mg per plate.
Results: The subacute oral toxicity test results did not reveal any marked changes in clinical characteristics. There were no toxicological changes related to RGO administration in hematological and serum biochemical characteristics in either control or treatment animals. Furthermore, no gross or histopathological changes related to RGO treatment were observed. The bacterial reverse mutation test results did not reveal, at any RGO concentration level and in all bacterial strains, any increase in the number of revertant colonies in the RGO treatment group compared to that in the negative control group.
Conclusion: The no-observed-adverse-effect level of RGO is greater than 2,000 mg/kg bw and RGO did not induce genotoxicity related to bacterial reverse mutations.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Chan E / 2010 / Interactions between traditional Chinese medicines and Western therapeutics / Curr Opin Drug Discov Devel 13 : 50 ~ 65
[학술지(정기간행물)] - Jordan SA / 2010 / Assessment of herbal medicinal products:Challenges, and opportunities to increase the knowledge base for safety assessment / Toxicol Appl Pharmacol 243 : 198 ~ 216
[학술지(정기간행물)] - Zhou S / 2004 / Predicting pharmacokinetic herbedrug interactions / Drug Metabol Drug Interact 20 : 143 ~ 158
[학술지(정기간행물)] - Choi RJ / 2015 / Ginseng: a panacea linking East Asia and North America? / Science 350 : S54 ~ S56
[학술지(정기간행물)] - Heo JH / 2008 / An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer’s disease / Eur J Neurol 15 : 865 ~ 868
[학술지(정기간행물)] - Jordan SA / 2010 / Assessment of herbal medicinal products:Challenges, and opportunities to increase the knowledge base for safety assessment / Toxicol Appl Pharmacol 243 : 198 ~ 216
[학술지(정기간행물)] - Zhou S / 2004 / Predicting pharmacokinetic herbedrug interactions / Drug Metabol Drug Interact 20 : 143 ~ 158
[학술지(정기간행물)] - Choi RJ / 2015 / Ginseng: a panacea linking East Asia and North America? / Science 350 : S54 ~ S56
[학술지(정기간행물)] - Heo JH / 2008 / An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer’s disease / Eur J Neurol 15 : 865 ~ 868
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UCI(KEPA) : I410-ECN-0101-2018-524-001599382