Evaluation of ginsenoside bioconversion of lactic acid bacteria isolated from kimchi

Boyeon Park; Hyelyeon Hwang; Jina Lee; Sung-Oh Sohn; Se Hee Lee; Min Young Jung; Hyeong In Lim; Hae Woong Park; Jong-Hee Lee

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자료유형: 학술저널

저자정보: Boyeon Park (World Institute of Kimchi) Hyelyeon Hwang (World Institute of Kimchi) Jina Lee (World Institute of Kimchi) Sung-Oh Sohn (World Institute of Kimchi) Se Hee Lee (World Institute of Kimchi) Min Young Jung (World Institute of Kimchi) Hyeong In Lim (World Institute of Kimchi) Hae Woong Park (World Institute of Kimchi) Jong-Hee Lee (World Institute of Kimchi)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.41 No.4

발행연도: 2017.10

수록면: 524 - 530 (7page)

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Background: Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation.
Methods: To investigate the bioconversion of ginsenoside Rb1, we prepared kimchi originated bacterial strains Leuconostoc mensenteroides WiKim19, Pediococcus pentosaceus WiKim20, Lactobacillus brevis WiKim47, Leuconostoc lactis WiKim48, and Lactobacillus sakei WiKim49 and analyzed bioconversion products using LC-MS/MS mass spectrometer.
Results: L. mesenteroides WiKim19 and Pediococcus pentosaceus WiKim20 converted ginsenoside Rb1 into the ginsenoside Rg3 approximately five times more than Lactobacillus brevis WiKim47, Leuconostoc lactis WiKim48, and Lactobacillus sakei WiKim49. L mesenteroides WIKim19 showed positive correlation with b-glucosidase activity and higher transformation ability of ginsenoside Rb1 into Rg3 than the other strains whereas, P. pentosaceus WiKim20 showed an elevated production of Rb3 even with lack of b-glucosidase activity but have the highest acidity among the five lactic acid bacteria (LAB).
Conclusion: Ginsenoside Rg5 concentration of five LABs have ranged from w2.6 mg/mL to 6.5 mg/mL and increased in accordance with the incubation periods. Our results indicate that the enzymatic activity along with acidic condition contribute to the production of minor ginsenoside from lactic acid bacteria.

#ginsenoside bioconversion #ginsenoside Rg3 #ginsenoside Rg5 #LC-MS/MS

참고문헌 (40)

참고문헌 신청

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[학술지(정기간행물)] - Setchell KD / 2002 / Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability / Am J Clin Nutr 76 : 447 ~ 453

[학술지(정기간행물)] - Chun J / 2007 / Conversion of isoflavone glucosides to aglycones in soymilk by fermentation with lactic acid bacteria / J Food Sci 72 : M39 ~ M44

[학술지(정기간행물)] - 김세화 / 2012 / Enzymatic Transformation of Ginsenoside Rb1 by Lactobacillus pentosus Strain 6105 from Kimchi / Journal of Ginseng Research 36 (3) : 291 ~ 297

[학술지(정기간행물)] - Quan LH / 2011 / Bioconversion of ginsenoside rb1 into compound k by Leuconostoc citreum LH1 isolated from kimchi / Braz J Microbiol 42 : 1227 ~ 1237

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Boyeon Park

소속기관 Bluebio Farm

주요연구분야 의약학 > 기타 의약학 자연과학 > 생물학

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Hyelyeon HWANG