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논문 기본 정보

자료유형
학술저널
저자정보
Dong-Hyun Kim (Kyung Hee University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.33 No.3
발행연도
2009.9
수록면
165 - 176 (12page)

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초록· 키워드

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Korean ginseng, which contains ginsenosides and polysaccharides as its main constituents, is orally administered to humans. Ginsenosides and polysaccharides are not easily absorbed by the body through the intestines due to their hydrophilicity. Therefore, these constituents which include ginsenosides Rb1, Rb2, and Rc, inevitably come into contact with intestinal microflora in the alimentary tract and can be metabolized by intestinal microflora. Since most of the metabolites such as compound K and protopanaxatriol are nonpolar compared to the parental components, these metabolites are easily absorbed from the gastrointestinal tract. The absorbed metabolites may express pharmacological actions, such as antitumor, antidiabetic, anti-inflammatory, anti-allergic, and neuroprotective effects. However, the activities that metabolize these constituents to bioactive compounds differ significantly between individuals because all individuals possess characteristic indigenous strains of intestinal bacteria. Recently, ginseng has been fermented with enzymes or microbes to develop ginsengs that contain these metabolites. However, before using these enzymes and probiotics, their safety and biotransforming activity should be assessed. Intestinal microflora play an important role in the pharmacological action of orally administered ginseng.

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Abstract
INTRODUCTION
METABOLISM OF BIOACTIVE CONSTITUENTS OF GINSENG
BIOLOGICAL ACTIVITY OF GINSENG METABOLITES
INDUSTRIAL APPLICATION
REFERENCES

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