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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 451 - 455 (5page)
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초록· 키워드
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Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters. EcRNH consisted of 308 amino acids and showed low similarity to endoribonucleases of other parasites (<40%). EcRNH had an active site centered on a putative DDEED motif instead of DEDD conserved in other species. A recombinant EcRNH produced as a soluble form in Escherichia coli showed enzymatic activity to cleave the 3"-O-P bond of RNA in a DNA-RNA duplex, producing 3"-hydroxyl and 5"-phosphate. These findings may contribute to develop antisense oligonucleotides which could damage echinostomes and other flukes.
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참고문헌 (12)
참고문헌 신청
[학술지(정기간행물)] - Yamashita J / 1964 / Echinostome / Progr Med Parasitol Japan 1 : 289 ~ 313
[학술지(정기간행물)] - Ando R / 1923 / On four new species of trematodes of the family Echinostomatidae / Dobutsugaku Zasshi 5 : 108 ~ 119
[학술지(정기간행물)] - Takahashi S / 1930 / A human case of Echinostoma cinetorchis / Tokyo Iji Shinshi 2 : 1326 ~ 1328
[학술지(정기간행물)] - Takahashi S / 1930 / The second human case of Echinostoma cinetorchis and a case of tapeworm in man / Tokyo Iji Shinshi 2 : 1326 ~ 1327
[학술지(정기간행물)] - Kawahara S / 1933 / Human cases of Echinostoma cinetorchis / Tokyo Iji Shinshi 2 : 1794 ~ 1796
[학술지(정기간행물)] - Ando R / 1923 / On four new species of trematodes of the family Echinostomatidae / Dobutsugaku Zasshi 5 : 108 ~ 119
[학술지(정기간행물)] - Takahashi S / 1930 / A human case of Echinostoma cinetorchis / Tokyo Iji Shinshi 2 : 1326 ~ 1328
[학술지(정기간행물)] - Takahashi S / 1930 / The second human case of Echinostoma cinetorchis and a case of tapeworm in man / Tokyo Iji Shinshi 2 : 1326 ~ 1327
[학술지(정기간행물)] - Kawahara S / 1933 / Human cases of Echinostoma cinetorchis / Tokyo Iji Shinshi 2 : 1794 ~ 1796
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UCI(KEPA) : I410-ECN-0101-2018-513-001258832