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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
- 수록면
- 41 - 58 (18page)
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초록· 키워드
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RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.
목차
ABSTRACT
INTRODUCTION
IMBALANCE OF TRANSCRIPTION AND TRANSLATIO IN T CELLS
ROLE OF RNA SPLICING IN T CELL HOMEOSTASIS
EPIGENETIC MODIFICATION OF RNA IN T CELLS
REGULATION OF RNA DECAY IN T CELLS
CONCLUSION
REFERENCES
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