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논문 기본 정보

자료유형
학술저널
저자정보
Ui-han Son (Kyungpook National University School of Medicine) Sylvatrie-Danne Dinzouna-Boutamba (Kyungpook National University School of Medicine) Sanghyun Lee (Korea National Institute of Health) Hae Soo Yun (Kyungpook National University School of Medicine) Jung-Yeon Kim (National Institute of Health) So-Young Joo (Kyungpook National University School of Medicine) Sookwan Jeong (Kyungpook National University School of Medicine) Man Hee Rhee (Kyungpook National University) Yeonchul Hong (Kyungpook National University School of Medicine) Dong-Il Chung (Kyungpook National University School of Medicine) Dongmi Kwak (Kyungpook National University) Youn-Kyoung Goo (Kyungpook National University School of Medicine)
저널정보
대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.55 No.2
발행연도
2017.4
수록면
149 - 158 (15page)

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Variant surface antigens (VSAs) encoded by pir families are considered to be the key proteins used by many Plasmodium spp. to escape the host immune system by antigenic variation. This attribute of VSAs is a critical issue in the development of a novel vaccine. In this regard, a population genetic study of vir genes from Plasmodium vivax was performed in the Republic of Korea (ROK). Eighty-five venous blood samples and 4 of the vir genes, namely vir 27, vir 21, vir 12, and vir 4, were selected for study. The number of segregating sites (S), number of haplotypes (H), haplotype diversity (Hd), DNA diversity (π and Θw), and Tajima’s D test value were conducted. Phylogenetic trees of each gene were constructed. The vir 21 (S=143, H=22, Hd=0.827) was the most genetically diverse gene, and the vir 4 (S=6, H=4, Hd=0.556) was the opposite one. Tajima’s D values for vir 27 (1.08530, P>0.1), vir 12 (2.89007, P<0.01), and vir 21 (0.40782, P>0.1) were positive, and that of vir 4 (-1.32162, P>0.1) was negative. All phylogenetic trees showed 2 clades with no particular branching according to the geographical differences and cluster. This study is the first survey on the vir genes in ROK, providing information on the genetic level. The sample sequences from vir 4 showed a clear difference to the Sal-1 reference gene sequence, whereas they were very similar to those from Indian isolates.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES

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